Synthesis and pH-dependent micellization of diblock copolymer mixtures

[en] This work focused on the preparation and the aqueous solution properties of hybrid polymeric micelles consisting of a hydrophobic poly(ε-caprolactone) (PCL) core and a mixed shell of hydrophilic poly(ethylene oxide) (PEO) and pH-sensitive poly(2-vinylpyridine) (P2VP). The hybrid micelles were successfully prepared by the rapid addition of acidic water to a binary solution of PCL34-b-PEO114 and PCL32-b-P2VP52 diblock copolymers in N,N-dimethylformamide. These micelles were pH-responsive as result of the pH-dependent ionization of the P2VP block. The impact of pH on the self-assembly of the binary mixture of diblocks—thus on the composition, shape, size and surface properties of the micelles—was studied by a variety of experimental techniques, i.e., dynamic and static light scattering, transmission electron microscopy, Zeta potential, fluorescence spectroscopy and complement hemolytic 50 test.

Research Center/Unit :

Center for Education and Research on Macromolecules (CERM)

Disciplines :

Chemistry
Materials science & engineering

Author, co-author :

Van Butsele, Kathy ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Sibret, Pierre ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Fustin, Charles-André; Université catholique de Louvain (UCL) > Chemistry of Inorganic and Organic Materials Unit (CMAT)

Gohy, Jean-François; Université catholique de Louvain (UCL) > Chemistry of Inorganic and Organic Materials Unit (CMAT)

Passirani, Catherine; University of Angers, France > Ingénierie de la Vectorisation Particulaire (Inserm)

Benoît, Jean-Pierre; University of Angers, France > Ingénierie de la Vectorisation Particulaire (Inserm)

Jérôme, Robert ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Jérôme, Christine ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Language :

English

Title :

Synthesis and pH-dependent micellization of diblock copolymer mixtures

Publication date :

15 January 2009

Journal title :

Journal of Colloid and Interface Science

ISSN :

0021-9797

eISSN :

1095-7103

Publisher :

Academic Press, Orlando, United States - Florida

Volume :

329

Issue :

Pages :

235-243

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://www.sciencedirect.com/science?_ob=MImg&_imagekey=B6WHR-4TKPVD9-1-W&_cdi=6857&_user=532038&_orig=browse&_coverDate=01%2F15%2F2009&_sk=996709997&view=c&wchp=dGLbVlz-zSkWb&md5=8333f600aee416bc7d2e51499c240834&ie=/sdarticle.pdf
http://www.elsevier.com/wps/find/journaldescription.cws_home/622861/description#description

Funders :

BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique
FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture
F.R.S.-FNRS - Fonds de la Recherche Scientifique

Commentary :

The authors acknowledge Journal of Colloid & Interface Science (Academic Press, Elsevier) for allowing them to archive this paper.

Available on ORBi :

since 27 January 2009

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Bibliography

Riess G. Prog. Polym. Sci. 28 (2003) 1107
Gohy J.-F. Adv. Polym. Sci. 190 (2005) 65
Kwon G.S., and Okano T. Adv. Drug Deliv. Rev. 21 (1996) 107
Jones M.C., and Leroux J.C. Eur. J. Pharm. Biopharm. 48 (1999) 101
In: Alexandridis P., and Lindman B. (Eds). Amphiphilic Block Copolymers: Self-Assembly and Applications (2000), Elsevier, Amsterdam
Kataoka K., Harada A., and Nagasaki Y. Adv. Drug Deliv. Rev. 47 (2001) 113
Torchilin V.P. Pharm. Res. 24 (2007) 1
Jerome C., and Lecomte P. Adv. Drug Deliv. Rev. 60 (2008) 1056
Voets I.K., de Keizer A., de Waard P., Frederik P.M., Bomans P.H.H., Schmalz H., Walther A., King S.M., Leermakers F.A.M., and Cohen Stuart M.A. Angew. Chem. Int. Ed. 45 (2006) 6673
Erhardt R., Zhang M., Boeker A., Zettl H., Abetz C., Frederik P., Krausch G., Abetz V., and Mueller A.H.E. J. Am. Chem. Soc. 125 (2003) 3260
Tian M., Qin A., Ramireddy C., Webber S.E., Munk P., Tuzar Z., and Prochazka K. Langmuir 9 (1993) 1741
Stepanek M., Podhajecka K., Tesarova E., Prochazka K., Tuzar Z., and Brown W. Langmuir 17 (2001) 4240
Podhajecka K., Stepanek M., Prochazka K., and Brown W. Langmuir 17 (2001) 4245
Matejicek P., Humpolickova J., Prochazka K., Tuzar Z., Spirkova M., Hof M., and Webber S.E. J. Phys. Chem. B 107 (2003) 8232
Garnier S., and Laschewsky A. Macromolecules 38 (2005) 7580
Dai S., Ravi P., Leong C.Y., Tam K.C., and Gan L.H. Langmuir 20 (2004) 1597
Petrov P., Bozukov M., Burkhardt M., Muthukrishnan S., Mueller A.H.E., and Tsvetanov C.B. J. Mater. Chem. 16 (2006) 2192
Patrickios C.S., Hertler W.R., Abbott N.L., and Hatton T.A. Macromolecules 27 (1994) 930
Chen W.-Y., Alexandridis P., Su C.-K., Patrickios C.S., Hertler W.R., and Hatton T.A. Macromolecules 28 (1995) 8604
Patrickios C.S., Lowe A.B., Armes S.P., and Billingham N.C. J. Polym. Sci. Part A Polym. Chem. 36 (1998) 617
Triftaridou A.I., Vamvakaki M., and Patrickios C.S. Polymer 43 (2002) 2921
Fustin C.A., Abetz V., and Gohy J.F. Eur. Phys. J. E Soft Matter 16 (2005) 291
Vangeyte P., and Jerome R. J. Polym. Sci. Part A Polym. Chem. 42 (2004) 1132
Aliabadi H.M., Mahmud A., Sharifabadi A.D., and Lavasanifar A. J. Controlled Release 104 (2005) 301
Shuai X., Ai H., Nasongkla N., Kim S., and Gao J. J. Controlled Release 98 (2004) 415
Park E.K., Kim S.Y., Lee S.B., and Lee Y.M. J. Controlled Release 109 (2005) 158
Hawker C.J., Hedrick J.L., Malmstroem E.E., Trollss M., Mecerreyes D., Moineau G., Dubois P., and Jerome R. Macromolecules 31 (1998) 213
Gravert D.J., and Janda K.D. Tetrahedron Lett. 39 (1998) 1513
Wohlrab S., and Kuckling D. J. Polym. Sci. Part A Polym. Chem. 39 (2001) 3797
Sauerbrey G. Z. Phys. 155 (1959) 206
E.A. Kabat, M.M. Mayer, Experimental Immunochemistry. second ed., 1961
Vittaz M., Bazile D., Spenlehauer G., Verrecchia T., Veillard M., Puisieux F., and Labarre D. Biomaterials 17 (1996) 1575
Passirani C., Barratt G., Devissaguet J.-P., and Labarre D. Life Sci. 62 (1998) 775
Passirani C., and Benoit J.-P. In: Mahato R.I. (Ed). Biomaterials for Delivery and Targeting of Proteins and Nucleic Acids (2000), CRC, Boca Raton 187
Vangeyte P., Leyh B., Heinrich M., Grandjean J., Bourgaux C., and Jerome R. Langmuir 20 (2004) 8442
Gref R., Luck M., Quellec P., Marchand M., Dellacherie E., Harnisch S., Blunk T., and Muller R.H. Colloids Surf. B 18 (2000) 301
Riley T., Stolnik S., Heald C.R., Xiong C.D., Garnett M.C., Illum L., Davis S.S., Purkiss S.C., Barlow R.J., and Gellert P.R. Langmuir 17 (2001) 3168
Disawal S., Qiu J., Elmore B.B., and Lvov Y.M. Colloids Surf. B 32 (2003) 145
Gohy J.-F., Willet N., Varshney S.K., Zhang J.-X., and Jerome R. E-Polymers (2002) Paper No 35
Vermette P., and Meagher L. Colloids Surf. B 28 (2003) 153
Lee J.H., and Oh S.H. J. Biomed. Mater. Res. 60 (2002) 44
Rieger J., Passirani C., Benoit J.-P., Van Butsele K., Jerome R., and Jerome C. Adv. Funct. Mater. 16 (2006) 1506
Vonarbourg A., Passirani C., Saulnier P., and Benoit J.-P. Biomaterials 27 (2006) 4356

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