self-assembly in solution; micelle; stimuli responsive micelle
Abstract :
[en] This work focused on the preparation and the aqueous solution properties of hybrid polymeric micelles consisting of a hydrophobic poly(ε-caprolactone) (PCL) core and a mixed shell of hydrophilic poly(ethylene oxide) (PEO) and pH-sensitive poly(2-vinylpyridine) (P2VP). The hybrid micelles were successfully prepared by the rapid addition of acidic water to a binary solution of PCL34-b-PEO114 and PCL32-b-P2VP52 diblock copolymers in N,N-dimethylformamide. These micelles were pH-responsive as result of the pH-dependent ionization of the P2VP block. The impact of pH on the self-assembly of the binary mixture of diblocks—thus on the composition, shape, size and surface properties of the micelles—was studied by a variety of experimental techniques, i.e., dynamic and static light scattering, transmission electron microscopy, Zeta potential, fluorescence spectroscopy and complement hemolytic 50 test.
Research Center/Unit :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry Materials science & engineering
Author, co-author :
Van Butsele, Kathy ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Sibret, Pierre ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Fustin, Charles-André; Université catholique de Louvain (UCL) > Chemistry of Inorganic and Organic Materials Unit (CMAT)
Gohy, Jean-François; Université catholique de Louvain (UCL) > Chemistry of Inorganic and Organic Materials Unit (CMAT)
Passirani, Catherine; University of Angers, France > Ingénierie de la Vectorisation Particulaire (Inserm)
Benoît, Jean-Pierre; University of Angers, France > Ingénierie de la Vectorisation Particulaire (Inserm)
Jérôme, Robert ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Jérôme, Christine ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Synthesis and pH-dependent micellization of diblock copolymer mixtures
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture F.R.S.-FNRS - Fonds de la Recherche Scientifique
Commentary :
The authors acknowledge Journal of Colloid & Interface Science (Academic Press, Elsevier) for allowing them to archive this paper.
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