self-assembly in solution; micelle; stimuli responsive micelle
Abstract :
[en] This work focused on the preparation and the aqueous solution properties of hybrid polymeric micelles consisting of a hydrophobic poly(ε-caprolactone) (PCL) core and a mixed shell of hydrophilic poly(ethylene oxide) (PEO) and pH-sensitive poly(2-vinylpyridine) (P2VP). The hybrid micelles were successfully prepared by the rapid addition of acidic water to a binary solution of PCL34-b-PEO114 and PCL32-b-P2VP52 diblock copolymers in N,N-dimethylformamide. These micelles were pH-responsive as result of the pH-dependent ionization of the P2VP block. The impact of pH on the self-assembly of the binary mixture of diblocks—thus on the composition, shape, size and surface properties of the micelles—was studied by a variety of experimental techniques, i.e., dynamic and static light scattering, transmission electron microscopy, Zeta potential, fluorescence spectroscopy and complement hemolytic 50 test.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry Materials science & engineering
Author, co-author :
Van Butsele, Kathy ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Sibret, Pierre ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Fustin, Charles-André; Université catholique de Louvain (UCL) > Chemistry of Inorganic and Organic Materials Unit (CMAT)
Gohy, Jean-François; Université catholique de Louvain (UCL) > Chemistry of Inorganic and Organic Materials Unit (CMAT)
Passirani, Catherine; University of Angers, France > Ingénierie de la Vectorisation Particulaire (Inserm)
Benoît, Jean-Pierre; University of Angers, France > Ingénierie de la Vectorisation Particulaire (Inserm)
Jérôme, Robert ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Jérôme, Christine ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Language :
English
Title :
Synthesis and pH-dependent micellization of diblock copolymer mixtures
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique FRIA - Fonds pour la Formation à la Recherche dans l'Industrie et dans l'Agriculture [BE] F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
Commentary :
The authors acknowledge Journal of Colloid & Interface Science (Academic Press, Elsevier) for allowing them to archive this paper.
Kwon G.S., and Okano T. Adv. Drug Deliv. Rev. 21 (1996) 107
Jones M.C., and Leroux J.C. Eur. J. Pharm. Biopharm. 48 (1999) 101
In: Alexandridis P., and Lindman B. (Eds). Amphiphilic Block Copolymers: Self-Assembly and Applications (2000), Elsevier, Amsterdam
Kataoka K., Harada A., and Nagasaki Y. Adv. Drug Deliv. Rev. 47 (2001) 113
Torchilin V.P. Pharm. Res. 24 (2007) 1
Jerome C., and Lecomte P. Adv. Drug Deliv. Rev. 60 (2008) 1056
Voets I.K., de Keizer A., de Waard P., Frederik P.M., Bomans P.H.H., Schmalz H., Walther A., King S.M., Leermakers F.A.M., and Cohen Stuart M.A. Angew. Chem. Int. Ed. 45 (2006) 6673
Erhardt R., Zhang M., Boeker A., Zettl H., Abetz C., Frederik P., Krausch G., Abetz V., and Mueller A.H.E. J. Am. Chem. Soc. 125 (2003) 3260
Tian M., Qin A., Ramireddy C., Webber S.E., Munk P., Tuzar Z., and Prochazka K. Langmuir 9 (1993) 1741
Stepanek M., Podhajecka K., Tesarova E., Prochazka K., Tuzar Z., and Brown W. Langmuir 17 (2001) 4240
Podhajecka K., Stepanek M., Prochazka K., and Brown W. Langmuir 17 (2001) 4245
Matejicek P., Humpolickova J., Prochazka K., Tuzar Z., Spirkova M., Hof M., and Webber S.E. J. Phys. Chem. B 107 (2003) 8232
Garnier S., and Laschewsky A. Macromolecules 38 (2005) 7580
Dai S., Ravi P., Leong C.Y., Tam K.C., and Gan L.H. Langmuir 20 (2004) 1597
Petrov P., Bozukov M., Burkhardt M., Muthukrishnan S., Mueller A.H.E., and Tsvetanov C.B. J. Mater. Chem. 16 (2006) 2192
