Reference : Cyclosporine a Inhibits Partially Spermine-Induced Differentiation but Not Cell Loss ...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Cyclosporine a Inhibits Partially Spermine-Induced Differentiation but Not Cell Loss of Suckling Rat Small Intestine
Peulen, Olivier mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Département des sciences biomédicales et précliniques >]
Dandrifosse, Guy mailto [Université de Liège - ULiège > Services généraux (Faculté de médecine) > Relations académiques et scientifiques (Médecine) >]
Digestive Diseases & Sciences
Yes (verified by ORBi)
[en] The polyamines are of great importance in several biological processes, such as cell proliferation, and differentiation. The ingestion of spermine by suckling rats induces the precocious maturation of their small intestine. This phenomenon is preceded by a cell elimination at the villus tip. We hypothesize that these two phenomena could be mediated by the immune system and thus inhibited by an immunosuppressive agent such as cyclosporine A. Cyclosporine A inhibits, at least partially, the spermine-induced increase of the maltase- and sucrase-specific activities in the small intestine but failed to inhibit lactase-specific activity decrease and cell loss. Spermine does not act by the same mechanism in differentiation and in cell loss. Moreover, spermine acts in a different way on lactase-specific activity compared to maltase- or sucrase-specific activity. We hypothesize that spermine acts on differentiation by a T-cell/IL-2-dependent mechanism.
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