Article (Scientific journals)
Destabilization Of A Model Membrane By A Predicted Fusion Peptide Of Fertilin Alpha
Schanck, A.; Brasseur, Robert; Peuvot, J.
1998In Journal de Chimie Physique et de Physico-Chimie Biologique, 95 (2), p. 467-473
Peer reviewed
 

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Abstract :
[en] The subunit a of the guinea pig fertilin (previously known as PH-30, an integral membrane protein involved in sperm-egg binding and fusion) is predicted to be a potential fusion protein.The structure of this putative fusion protein was analysed by molecular modeling and we have found a peptidic sequence of 17 residues (D83-P99) organized in helix that inserts obliquely in lipid phases. The effect of ths synthesized peptide was studied on a model membrane by 3lP NMR and light scattering. It appears to increase the size of lipid vesicles and induces structural odifications. We interpret these observations as a destabilization of the lipid organization by this peptide because of its tilted insertion in phospholipid layers. This destabilization could favor membrane fusion.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Schanck, A.
Brasseur, Robert ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech
Peuvot, J.
Language :
English
Title :
Destabilization Of A Model Membrane By A Predicted Fusion Peptide Of Fertilin Alpha
Publication date :
1998
Journal title :
Journal de Chimie Physique et de Physico-Chimie Biologique
ISSN :
0021-7689
eISSN :
1878-7169
Publisher :
John Wiley & Sons, United Kingdom
Volume :
95
Issue :
2
Pages :
467-473
467-73
Peer reviewed :
Peer reviewed
Available on ORBi :
since 29 June 2010

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