Aminoglycoside Antibiotics Prevent The Formation Of Non-Bilayer Structures In Negatively-Charged Membranes. Comparative Studies Using Fusogenic (Bis(Beta-Diethylaminoethylether)Hexestrol) And Aggregating (Spermine) Agents

Vanbambeke, F.; Mingeot-Leclercq, Marie-Paule; Brasseur, Robert; Tulkens, Pm.; Schanck, A.

doi:10.1016/0009-3084(95)02520-0

Article (Scientific journals)

Aminoglycoside Antibiotics Prevent The Formation Of Non-Bilayer Structures In Negatively-Charged Membranes. Comparative Studies Using Fusogenic (Bis(Beta-Diethylaminoethylether)Hexestrol) And Aggregating (Spermine) Agents

Vanbambeke, F.; Mingeot-Leclercq, Marie-Paule; Brasseur, Robert et al.

1996 • In Chemistry and Physics of Lipids, 79 (2), p. 123-135

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https://hdl.handle.net/2268/64248

DOI
10.1016/0009-3084(95)02520-0

PubMed
8640900

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Abstract :

[en] Aminoglycoside antibiotics cause aggregation but not fusion of negatively-charged liposomes at an extent proportional to their capacity to interact with acidic phospholipids (Van Bambeke et al., 1995, Eur. J. Pharmacol., 289, 321-333). To understand why aggregation is not followed by fusion, we have examined here the influence of two aminoglycosides with markedly different toxic potential (gentamicin > isepamicin) on lipid phase transition in negatively-charged liposomes using 31P-NMR spectroscopy, in comparison with spermine (an aggregating agent) and bis(beta-diethylaminoethylether)hexestrol or DEH (a fusogenic cationic amphiphile). Gentamicin, spermine, and, to a lesser extent, isepamicin inhibit the appearance of the isotropic signal seen upon warming of control liposomes and denoting the presence of mobile structures. This non-bilayer signal appeared most prominently when liposomes were incubated with DEH, a strong fusogenic agent. We conclude that aminoglycosides, like spermine, have the potential to prevent membrane fusion, by inhibiting the development of a critical change in membrane organization, which is associated with fusion. We suggest that this capacity could be a determinant in aminoglycoside toxicity.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Vanbambeke, F.

Mingeot-Leclercq, Marie-Paule

Brasseur, Robert ; Université de Liège - ULiège > Gembloux Agro-Bio Tech

Tulkens, Pm.

Schanck, A.

Language :

English

Title :

Publication date :

1996

Journal title :

Chemistry and Physics of Lipids

ISSN :

0009-3084

Publisher :

Elsevier, Netherlands

Volume :

Issue :

Pages :

123-135
123-35

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 28 June 2010

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