Reference : Genetic, molecular and clinical features of familial isolated pituitary adenomas.
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
http://hdl.handle.net/2268/64167
Genetic, molecular and clinical features of familial isolated pituitary adenomas.
English
Daly, Adrian [Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie >]
Tichomirowa, M. A. [> > > >]
Beckers, Albert mailto [Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie >]
2009
Hormone Research
S. Karger
71
Suppl 2
116-122
Yes (verified by ORBi)
International
0301-0163
1423-0046
Basel
Switzerland
[en] Animals ; Genetic Diseases, Inborn/genetics/metabolism/pathology/physiopathology ; Humans ; Intracellular Signaling Peptides and Proteins/genetics/metabolism ; Pituitary Neoplasms/genetics/metabolism/pathology/physiopathology ; Proto-Oncogene Proteins/genetics/metabolism
[en] Pituitary adenomas occur in a familial setting in about 5% of all cases, and over half of these are due to multiple endocrine neoplasia type 1 (MEN1) and Carney's complex (CNC). Non-MEN1/CNC familial pituitary tumours of all tumour phenotypes, known as familial isolated pituitary adenomas (FIPA), were first described in the late 1990s. Clinical features of FIPA differ from those of sporadic pituitary adenomas, as patients with FIPA have a younger age at diagnosis and larger tumours. About 15% of patients with FIPA have mutations in the aryl hydrocarbon receptor-interacting protein gene (AIP), which indicates that FIPA may have a diverse genetic pathophysiology. This article describes the clinical features of FIPA, the tumour pathologies found in this setting and the genetic/molecular data that have recently been reported in FIPA.
Researchers ; Professionals
http://hdl.handle.net/2268/64167
10.1159/000192448
Copyright 2009 S. Karger AG, Basel.

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