Reference : Sequential positron emission tomography using [18F]fluorodeoxyglucose for monitoring ...
Scientific journals : Article
Human health sciences : Radiology, nuclear medicine & imaging
http://hdl.handle.net/2268/6410
Sequential positron emission tomography using [18F]fluorodeoxyglucose for monitoring response to chemotherapy in metastatic breast cancer.
English
Couturier, Olivier [> > > >]
Jerusalem, Guy mailto [Centre Hospitalier Universitaire de Liège - CHU > > Oncologie médicale >]
N'Guyen, Jean-Michel [> > > >]
Hustinx, Roland mailto [Centre Hospitalier Universitaire de Liège - CHU > > Médecine nucléaire >]
2006
Clinical Cancer Research
American Association for Cancer Research, Inc. (AACR)
12
21
6437-43
Yes (verified by ORBi)
International
1078-0432
1557-3265
Birmingham
AL
[en] Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Breast Neoplasms/drug therapy/mortality/radionuclide imaging ; Disease-Free Survival ; Female ; Fluorodeoxyglucose F18/diagnostic use ; Humans ; Neoplasm Metastasis/drug therapy/radionuclide imaging ; Positron-Emission Tomography ; Survival Analysis ; Treatment Outcome
[en] PURPOSE: To evaluate the clinical value of positron emission tomography (PET) for monitoring chemotherapy in metastatic breast cancer. EXPERIMENTAL DESIGN: Twenty patients with hormonorefractory or hormonoreceptor-negative multimetastatic breast cancer were prospectively included. PET studies were done at baseline, at day 21 after the first cycle and at day 21 after the third cycle of chemotherapy. Metabolic response was defined based on visual and various modes of standardized uptake value (SUV) analysis of sequential PET studies. RESULTS: After one cycle, PET indicated a partial response in 12 patients, stable disease in 7 patients, and progressive disease in 1 patient, according to the visual analysis. After three cycles, PET showed a complete response in 5 patients, partial response in 11 patients, stable disease in 3 patients, and progressive disease in 1 patient. Seventy-five percent of the patients showing a metabolic response on visual analysis effectively responded to the treatment. The average SUV decreased on both the second and the third PET study, but only changes measured after three cycles of chemotherapy predicted the clinical response to chemotherapy and the overall survival. All methods for calculating the SUV (normalized for body weight, body surface area, or lean body mass) provided similar results. CONCLUSION: Semiquantitative analysis of [18F]fluorodeoxyglucose-PET studies done after three cycles of chemotherapy is useful for monitoring the response to chemotherapy in metastatic breast cancer.
http://hdl.handle.net/2268/6410
also: http://hdl.handle.net/2268/5231
10.1158/1078-0432.CCR-06-0383

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