Piracetam-Induced Changes To Membrane Physical-Properties - A Combined Approach By P-31 Nuclear-Magnetic-Resonance And Conformational-Analysis

Peuvot, J.; Schanck, A.; Deleers, M.; Brasseur, Robert

doi:10.1016/0006-2952(95)00225-O

Article (Scientific journals)

Piracetam-Induced Changes To Membrane Physical-Properties - A Combined Approach By P-31 Nuclear-Magnetic-Resonance And Conformational-Analysis

Peuvot, J.; Schanck, A.; Deleers, M. et al.

1995 • In Biochemical Pharmacology, 50 (8), p. 1129-1134

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https://hdl.handle.net/2268/63794

DOI
10.1016/0006-2952(95)00225-O

PubMed
7488225

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Abstract :

[en] Piracetam, Nootropil (2-oxo-1-pyrrolidine acetamide), is a drug promoting erythrocyte deformability. To establish the mode of action of this compound, we have investigated its influence on the organization of model phospholipid membranes. 31P NMR data show that the drug induces a structural modification in liposomes made of phosphatidylcholine and phosphatidylethanolamine. Our conformational analysis results have allowed the interpretation of the effect of piracetam on these model membranes: the specific interaction between the drug molecules and the phosphate headgroups induces a new organization of the lipids favouring formation of mobile drug-phospholipid complexes that exhibit an isotropic-type signal in the 31P NMR spectra.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Peuvot, J.

Schanck, A.

Deleers, M.

Brasseur, Robert ; Université de Liège - ULiège > Gembloux Agro-Bio Tech

Language :

English

Title :

Piracetam-Induced Changes To Membrane Physical-Properties - A Combined Approach By P-31 Nuclear-Magnetic-Resonance And Conformational-Analysis

Publication date :

1995

Journal title :

Biochemical Pharmacology

ISSN :

0006-2952

eISSN :

1873-2968

Publisher :

Elsevier, Netherlands

Volume :

Issue :

Pages :

1129-1134
1129-34

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 June 2010

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