Article (Scientific journals)
Piracetam-Induced Changes To Membrane Physical-Properties - A Combined Approach By P-31 Nuclear-Magnetic-Resonance And Conformational-Analysis
Peuvot, J.; Schanck, A.; Deleers, M. et al.
1995In Biochemical Pharmacology, 50 (8), p. 1129-1134
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Abstract :
[en] Piracetam, Nootropil (2-oxo-1-pyrrolidine acetamide), is a drug promoting erythrocyte deformability. To establish the mode of action of this compound, we have investigated its influence on the organization of model phospholipid membranes. 31P NMR data show that the drug induces a structural modification in liposomes made of phosphatidylcholine and phosphatidylethanolamine. Our conformational analysis results have allowed the interpretation of the effect of piracetam on these model membranes: the specific interaction between the drug molecules and the phosphate headgroups induces a new organization of the lipids favouring formation of mobile drug-phospholipid complexes that exhibit an isotropic-type signal in the 31P NMR spectra.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Peuvot, J.
Schanck, A.
Deleers, M.
Brasseur, Robert ;  Université de Liège - ULiège > Gembloux Agro-Bio Tech
Language :
English
Title :
Piracetam-Induced Changes To Membrane Physical-Properties - A Combined Approach By P-31 Nuclear-Magnetic-Resonance And Conformational-Analysis
Publication date :
1995
Journal title :
Biochemical Pharmacology
ISSN :
0006-2952
eISSN :
1873-2968
Publisher :
Elsevier, Netherlands
Volume :
50
Issue :
8
Pages :
1129-1134
1129-34
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 25 June 2010

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