[en] Piracetam, Nootropil (2-oxo-1-pyrrolidine acetamide), is a drug promoting
erythrocyte deformability. To establish the mode of action of this compound, we
have investigated its influence on the organization of model phospholipid
membranes. 31P NMR data show that the drug induces a structural modification in
liposomes made of phosphatidylcholine and phosphatidylethanolamine. Our
conformational analysis results have allowed the interpretation of the effect of
piracetam on these model membranes: the specific interaction between the drug
molecules and the phosphate headgroups induces a new organization of the lipids
favouring formation of mobile drug-phospholipid complexes that exhibit an
isotropic-type signal in the 31P NMR spectra.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Peuvot, J.
Schanck, A.
Deleers, M.
Brasseur, Robert ; Université de Liège - ULiège > Gembloux Agro-Bio Tech
Language :
English
Title :
Piracetam-Induced Changes To Membrane Physical-Properties - A Combined Approach By P-31 Nuclear-Magnetic-Resonance And Conformational-Analysis
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