Reference : Bage - A New Gene Encoding An Antigen Recognized On Human Melanomas By Cytolytic T-Ly...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Bage - A New Gene Encoding An Antigen Recognized On Human Melanomas By Cytolytic T-Lymphocytes
Boel, P. [ > > ]
Wildmann, C. [> > > >]
Sensi, Ml. [> > > >]
Brasseur, Robert mailto [Université de Liège - ULiège > > Gembloux Agro-Bio Tech >]
Renauld, Jc. [> > > >]
Coulie, P. [> > > >]
Boon, T. [> > > >]
Vanderbruggen, P. [> > > >]
Yes (verified by ORBi)
[en] Several tumor antigens are recognized by autologous cytolytic T lymphocytes (CTL)
on human melanoma MZ2-MEL. Some of them are encoded by genes MAGE-1 and MAGE-3,
which are not expressed in normal tissues except in testis. Here, we report the
identification of a new gene that codes for another of these antigens. This gene,
named BAGE, codes for a putative protein of 43 aa and seems to belong to a family
of several genes. The antigen recognized by the autologous CTL consists of
BAGE-encoded peptide AARAVFLAL bound to an HLA-Cw 1601 molecule. Gene BAGE is
expressed in 22% of melanomas, 30% of infiltrating bladder carcinomas, 10% of
mammary carcinomas, 8% of head and neck squamous cell carcinomas, and 6% of
non-small cell lung carcinomas. Like the MAGE genes, it is silent in normal
tissues with the exception of testis. Because of its tumor-specific expression,
the BAGE-encoded antigen may prove useful for cancer immunotherapy.
Researchers ; Professionals

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