Tilted Peptides: A Motif For Membrane Destabilization (Hypothesis)

[en] Cell life depends on the dynamics of molecular processes: molecule folding, organelle building and transformations involving membrane fusion, protein activation and degradation. To carry out these processes, the hydrophilic/hydrophobic interfaces of amphipathic systems such as membranes and native proteins must be disrupted. In the past decade, protein fragments acting in the disruption of interfaces have been evidenced: they are named the tilted or oblique peptides. Due to a peculiar distribution of hydrophobicity, they can disrupt hydrophobicity interfaces. Tilted peptides should be present in many proteins involved in various stages of cell life. This hypothesis overviews their discovery, describes how they are detected and discusses how they could be involved in dynamic biological processes.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Brasseur, Robert ; Université de Liège - ULiège > Gembloux Agro-Bio Tech

Language :

English

Title :

Tilted Peptides: A Motif For Membrane Destabilization (Hypothesis)

Publication date :

2000

Journal title :

Molecular Membrane Biology

ISSN :

0968-7688

eISSN :

1464-5203

Publisher :

Taylor & Francis, United Kingdom

Volume :

Issue :

Pages :

31-40
31-40

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 25 June 2010

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1 (1 by ULiège)

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