Reference : Identification of differentially expressed genes in the zebrafish hypothalamic-pituit...
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Identification of differentially expressed genes in the zebrafish hypothalamic-pituitary axis.
Toro, Sabrina [> > > >]
Wegner, Jeremy [> > > >]
Muller, Marc mailto [Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire >]
Westerfield, Monte [> > > >]
Varga, Zoltan M [> > > >]
Gene Expression Patterns
Elsevier Science
Yes (verified by ORBi)
The Netherlands
[en] Animals ; Embryo, Nonmammalian/embryology/metabolism ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Gene Library ; Hypothalamo-Hypophyseal System/embryology/growth & development/metabolism ; In Situ Hybridization ; Larva/genetics/growth & development ; Pituitary-Adrenal System/embryology/growth & development/metabolism ; Zebrafish/embryology/genetics/growth & development ; Zebrafish Proteins/genetics
[en] The vertebrate hypothalamic-pituitary axis (HP) is the main link between the central nervous system and endocrine system. Although several signal pathways and regulatory genes have been implicated in adenohypophysis ontogenesis, little is known about hypothalamic-neurohypophysial development or when the HP matures and becomes functional. To identify markers of the HP, we constructed subtractive cDNA libraries between adult zebrafish hypothalamus and pituitary. We identified previously published genes, ESTs and novel zebrafish genes, some of which were predicted by genomic database analysis. We also analyzed expression patterns of these genes and found that several are expressed in the embryonic and larval hypothalamus, neurohypophysis, and/or adenohypophysis. Expression at these stages makes these genes useful markers to study HP maturation and function.
Applied and Fundamental FISH Research Center - AFFISH-RC ; Giga-Development and Stem Cells

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