Article (Scientific journals)
Identification of differentially expressed genes in the zebrafish hypothalamic-pituitary axis.
Toro, Sabrina; Wegner, Jeremy; Muller, Marc et al.
2009In Gene Expression Patterns, 9 (4), p. 200-8
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Keywords :
Animals; Embryo, Nonmammalian/embryology/metabolism; Gene Expression Profiling; Gene Expression Regulation, Developmental; Gene Library; Hypothalamo-Hypophyseal System/embryology/growth & development/metabolism; In Situ Hybridization; Larva/genetics/growth & development; Pituitary-Adrenal System/embryology/growth & development/metabolism; Zebrafish/embryology/genetics/growth & development; Zebrafish Proteins/genetics
Abstract :
[en] The vertebrate hypothalamic-pituitary axis (HP) is the main link between the central nervous system and endocrine system. Although several signal pathways and regulatory genes have been implicated in adenohypophysis ontogenesis, little is known about hypothalamic-neurohypophysial development or when the HP matures and becomes functional. To identify markers of the HP, we constructed subtractive cDNA libraries between adult zebrafish hypothalamus and pituitary. We identified previously published genes, ESTs and novel zebrafish genes, some of which were predicted by genomic database analysis. We also analyzed expression patterns of these genes and found that several are expressed in the embryonic and larval hypothalamus, neurohypophysis, and/or adenohypophysis. Expression at these stages makes these genes useful markers to study HP maturation and function.
Research Center/Unit :
AFFISH-RC - Applied and Fundamental FISH Research Center - ULiège
Giga-Development and Stem Cells - ULiège
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Toro, Sabrina
Wegner, Jeremy
Muller, Marc  ;  Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Westerfield, Monte
Varga, Zoltan M
Language :
English
Title :
Identification of differentially expressed genes in the zebrafish hypothalamic-pituitary axis.
Publication date :
2009
Journal title :
Gene Expression Patterns
ISSN :
1567-133X
Publisher :
Elsevier Science, Amsterdam, Netherlands
Volume :
9
Issue :
4
Pages :
200-8
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 24 June 2010

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