Unsuccessful Induction of Endometriosis in Female Rhesus Macaques (Macaca mulatta).

[en] Background/Aims: The aim of this study was to induce endometriosis in female rhesus macaques (Macaca mulatta) for research purposes. Methods: Three female monkeys from 4 to 4.5 years of age underwent three consecutive attempts at endometriosis induction over an 8-month period: (i) the first attempt involved intravaginal sampling of endometrial tissue and transplantation into the intrapelvic cavity; (ii) the second entailed surgical removal of endometrium after hysterotomy and intra-abdominal placement, and (iii) the third used endometrial mucosa obtained by scraping the uterus after hysterectomy, placed in a surgical pouch created in the retrovesical space (Retzius). In each case, the pelvic cavity was closely inspected after 7, 9, and 6 weeks respectively for the presence of endometriotic lesions, and peritoneal biopsies were performed. Results: Neither macroscopic observation nor histological analysis revealed any endometriotic lesions. Conclusion: This failure to induce endometriosis in female rhesus macaques suggests that this species is not the most efficient experimental model among primates to investigate endometriosis development or treatment.

Disciplines :

Anatomy (cytology, histology, embryology...) & physiology

Author, co-author :

Defrère, S.

Squifflet, J.

Lousse, J. C.

Van Langendonck, A.

Gonzalez-Ramos, R.

Foidart, Jean-Michel ; Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement

Jérôme, Christine ; Université de Liège - ULiège > Département de chimie (sciences) > Centre d'études et de rech. sur les macromolécules (CERM) - Chimie des macromolécules et des matériaux organiques

Delattre, Luc ; Université de Liège - ULiège > Département de pharmacie > Département de pharmacie

Donnez, J.

Dehoux, J. P.

Language :

English

Title :

Unsuccessful Induction of Endometriosis in Female Rhesus Macaques (Macaca mulatta).

Publication date :

April 2008

Journal title :

Gynecologic and Obstetric Investigation

ISSN :

0378-7346

eISSN :

1423-002X

Publisher :

S. Karger, Basel, Switzerland

Volume :

Issue :

Pages :

84-90

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 24 June 2010

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