Reference : Unsuccessful Induction of Endometriosis in Female Rhesus Macaques (Macaca mulatta).
Scientific journals : Article
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
Unsuccessful Induction of Endometriosis in Female Rhesus Macaques (Macaca mulatta).
Defrère, S. [ > > ]
Squifflet, J. [ > > ]
Lousse, J. C. [ > > ]
Van Langendonck, A. [ > > ]
Gonzalez-Ramos, R. [ > > ]
Foidart, Jean-Michel mailto [Université de Liège - ULiège > Département des sciences cliniques > Gynécologie - Obstétrique - Labo de biologie des tumeurs et du développement >]
Jérôme, Christine mailto [Université de Liège - ULiège > Département de chimie (sciences) > Centre d'études et de rech. sur les macromolécules (CERM) - Chimie des macromolécules et des matériaux organiques >]
Delattre, Luc mailto [Université de Liège - ULiège > Département de pharmacie > Département de pharmacie >]
Donnez, J. [ > > ]
Dehoux, J. P. [ > > ]
Gynecologic & Obstetric Investigation
S. Karger
Yes (verified by ORBi)
[en] Animal model ; Endometriosis ; Macaca mulatta ; Primate ; Rhesus monkey
[en] Background/Aims: The aim of this study was to induce endometriosis in female rhesus macaques (Macaca mulatta) for research purposes. Methods: Three female monkeys from 4 to 4.5 years of age underwent three consecutive attempts at endometriosis induction over an 8-month period: (i) the first attempt involved intravaginal sampling of endometrial tissue and transplantation into the intrapelvic cavity; (ii) the second entailed surgical removal of endometrium after hysterotomy and intra-abdominal placement, and (iii) the third used endometrial mucosa obtained by scraping the uterus after hysterectomy, placed in a surgical pouch created in the retrovesical space (Retzius). In each case, the pelvic cavity was closely inspected after 7, 9, and 6 weeks respectively for the presence of endometriotic lesions, and peritoneal biopsies were performed. Results: Neither macroscopic observation nor histological analysis revealed any endometriotic lesions. Conclusion: This failure to induce endometriosis in female rhesus macaques suggests that this species is not the most efficient experimental model among primates to investigate endometriosis development or treatment.

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