The "Tilted Peptide Theory" links membrane insertion properties and fusogenicity of viral fusion peptides.

Amino Acid Sequence; Humans; Lipid Metabolism; Models, Biological; Molecular Sequence Data; Mutation; Peptides/chemistry/genetics/metabolism; Viral Fusion Proteins/chemistry/genetics/metabolism; Virus Internalization

Abstract :

[en] Class I fusion glycoproteins of viruses are involved in the fusion between viral envelope and cell membrane. A region located in the N-terminal domain of these glycoproteins, called the fusion peptide, is essential for fusion. Fusion peptides are able to induce by themselves in vitro membrane fusion. In this paper, we review the properties of those peptides related to their fusogenicity, in particular the correlation existing between their ability to insert obliquely in membranes and fusogenicity. This relation notably allows predicting successfully the minimal region of some fusion peptides sufficient to induce significant in vitro fusion. The notion of obliquity and fusogenicity is discussed in terms of the existing proposed mechanisms for viral fusion.

Disciplines :

Biochemistry, biophysics & molecular biology

Author, co-author :

Charloteaux, Benoît ; Université de Liège - ULiège > Gembloux Agro-Bio Tech

Lorin, Aurélien

Brasseur, Robert ; Université de Liège - ULiège > Gembloux Agro-Bio Tech

Lins, Laurence ; Université de Liège - ULiège > Gembloux Agro-Bio Tech

Language :

English

Title :

The "Tilted Peptide Theory" links membrane insertion properties and fusogenicity of viral fusion peptides.

Publication date :

2009

Journal title :

Protein and Peptide Letters

ISSN :

0929-8665

Publisher :

Bentham Science Publishers Ltd., Hilversum, Netherlands

Volume :

Issue :

Pages :

718-25

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 23 June 2010

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