Article (Scientific journals)
Pharmacokinetic study of a new testosterone-in-adhesive matrix patch applied every 2 days to hypogonadal men.
Raynaud, J. P.; Aumonier, C.; Gualano, V. et al.
2008In Journal of Steroid Biochemistry and Molecular Biology, 109 (1-2), p. 177-184
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Keywords :
Adhesiveness; Adhesives; Administration, Cutaneous; Adolescent; Adult; Aged; Cross-Over Studies; Delayed-Action Preparations; Drug Delivery Systems; Drug Tolerance; Half-Life; Humans; Hypogonadism/blood/drug therapy; Male; Middle Aged; Safety; Testosterone/administration & dosage/adverse effects/blood/pharmacokinetics
Abstract :
[en] The present study assessed pharmacokinetic testosterone time profile and dose proportionality after application of a new matrix testosterone patch (30, 45, and 60 cm2 containing 0.5mg of testosterone per cm2). This open study was a single dose, three-period, crossover trial with a randomised treatment sequence in 24 hypogonadal men, consisting in a single 48-h application of two patches of 2x 30 cm2, 2x 45 cm2, 2x 60 cm2, separated by a 5-day wash-out. Testosterone concentrations were determined during patch application and after patch removal. Dose proportionality was assessed on baseline corrected, dose normalised parameters for C av,corr/D, C max,corr/D and AUC(0-48),corr/D. Testosterone concentrations rose during the first 9h following patch application, remained relatively sustained until 48 h and then decreased abruptly after patch removal, with a half-life of 1.3h. Testosterone levels were maintained above 3 ng/mL for 42-45 h with all patches. C av were 3.39, 4.03 and 4.58 ng/mL and Cmax were 4.33, 5.29 and 6.18 ng/mL according to the doses. AUC 0-48), C av and Cmax were dose dependent with mean ratios within the acceptance range (0.70-1.43). In conclusion, dose linearity was demonstrated between the different strengths of testosterone patches. Application resulted in dose proportional increases in serum T levels in hypogonadal men into the low to mid-normal range within the first hours and achieved steady state for 48 h. During this short term study with three consecutive patch applications, this patch was shown to be efficient, convenient and safe with excellent adhesiveness and skin tolerability, and with no cross-contamination to partner or to environment.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Raynaud, J. P.
Aumonier, C.
Gualano, V.
Betea, Daniela ;  Université de Liège - ULiège > Endocrinologie clinique
Beckers, Albert ;  Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie
Language :
English
Title :
Pharmacokinetic study of a new testosterone-in-adhesive matrix patch applied every 2 days to hypogonadal men.
Publication date :
March 2008
Journal title :
Journal of Steroid Biochemistry and Molecular Biology
ISSN :
0960-0760
eISSN :
1879-1220
Publisher :
Pergamon Press, Oxford, United Kingdom
Volume :
109
Issue :
1-2
Pages :
177-184
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 June 2010

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