Reference : Antimicrobial activity against gram negative bacilli from Yaounde Central Hospital, C...
Scientific journals : Article
Life sciences : Microbiology
Antimicrobial activity against gram negative bacilli from Yaounde Central Hospital, Cameroon
Gangoue Pieboji, Joseph mailto [Institut de Recherches Médicales et d'étude des plantes médicinales-IMPM-Cameroun > > > >]
Koulla-Shiro, S. [> > > >]
Ngassam, P. [> > > >]
Adiogo, D. [> > > >]
Ndumbe, P. [> > > >]
African Health Sciences
Yes (verified by ORBi)
[en] Anti-Infective Agents/administration & dosage/pharmacology/*therapeutic ; use ; Cameroon ; *Drug Resistance, Bacterial ; Gram-Negative Bacteria/*drug effects/isolation & purification ; Humans ; Microbial Sensitivity Tests
[en] BACKGROUND: Antimicrobial resistance among bacteria pathogens is a world-wide issue. The antimicrobial susceptibility patterns of common pathogenic bacteria are essential to guide empirical and pathogen-specific therapy; unfortunately, these data are scarse in Cameroon. OBJECTIVE: To determine the antimicrobial susceptibility patterns of Gram-negative bacilli isolated in Yaounde Central Hospital Laboratory of Bacteriology. METHODS: Gram-negative bacilli isolates (n = 505), obtained from a wide range of clinical specimens (urine, pus and blood) in Yaounde Central Hospital Laboratory of Bacteriology between March 1995 and April 1998, were evaluated for resistance to antibiotics (amoxicillin, amoxicillin/clavulanate, piperacillin, cefazolin, cefoxitin, cefotaxime, ceftazidime, aztreonam, imipenem, gentamicin, tobramicin, ofloxacin and trimethoprim/sulfamethoxazole) by the Kirby-Bauer disk diffusion method. RESULTS: High rates of resistance were found in most of the bacteria studied. Resistance to all isolates was mostly observed for amoxicillin (87%), piperacillin (74%) and trimethoprim/sulfamethoxazole (73%). Susceptibilities to third generation cephalosporins (cefotaxime, ceftazidime) and monobactame (aztreonam) were = 91% for Escherichia coli, = 71% for Klebsiella spp., = 98% for Proteus mirabilis, = 50% for Enterobacter spp. and Citrobacter spp. Pseudomonas aeruginosa was less susceptible to cefotaxime (2%) and aztreonam (33%), and highly susceptible to ceftazidime (72%) whereas Acinetobacter baumannii was highly resistant to aztreonam (100%), to cefotaxime (96%) and cetazidime (62%). Imipenem (98%) was the most active antibiotic followed by the ofloxacine (88%). Susceptibility of all isolates to gentamicin was 67%. CONCLUSION: These results indicate that surveillance to antimicrobial resistance in Cameroon is necessary to monitor microbial trends, antimicrobial resistance pattern, and provide information for choosing empirical or direct therapy to physicians.

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