Reference : Calcium chez les patients hemodialyses : calcemie totale ou calcium ionise ? Le labor...
Scientific journals : Article
Human health sciences : Urology & nephrology
Human health sciences : Laboratory medicine & medical technology
Calcium chez les patients hemodialyses : calcemie totale ou calcium ionise ? Le laboratoire doit-il systematiquement fournir au clinicien une valeur de calcemie totale corrigee obtenue par calcul ?
[en] Plasma calcium in haemodialysis patients: total calcium or ionized calcium? Should we systematically provide a value of total corrected calcium on our protocols?
Monfort, Mélanie [Centre Hospitalier Universitaire de Liège - CHU > > Frais communs Biologie Clinique >]
Delanaye, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Néphrologie >]
Chapelle, Jean-Paul mailto [Université de Liège - ULiège > Département de pharmacie > Chimie médicale >]
Cavalier, Etienne mailto [Centre Hospitalier Universitaire de Liège - CHU > > Chimie médicale >]
Annales de Biologie Clinique
John Libbey Eurotext
Yes (verified by ORBi)
[en] Ionized calcium is the only physiologically active form of calcium. Because of the variation of albumin, pH and haemoconcentration observed during haemodialysis session in patients with chronic renal failure, measure of total calcium does not reflect the real variation of ionized calcium. However, many formulae to correct total calcium by albumin have been proposed but none of them has been validated in dialysis patients. At present time, computing progress permit laboratory to systematically provide a value of corrected total calcium on protocols but is it really indicated? Our results showed that any of those formulae allows obtaining a value of total calcium that possesses a significant critical difference in relation to total calcium. Thus, correction formulae must be abandoned in aid of ionized calcium in haemodialysis patients.
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