Reference : Tandem high-dose therapy (HDT) for multiple myeloma: recombinant human erythropoietin...
Scientific journals : Article
Human health sciences : Hematology
http://hdl.handle.net/2268/6289
Tandem high-dose therapy (HDT) for multiple myeloma: recombinant human erythropoietin therapy given between first and second HDT allows second peripheral blood stem cell transplantation without red blood cell transfusion.
English
Baron, Frédéric mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Frere, Pascale mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Fillet, Georges mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
Beguin, Yves mailto [Centre Hospitalier Universitaire de Liège - CHU > > Hématologie clinique >]
2003
British Journal of Haematology
Blackwell Publishing
123
1
103-5
Yes (verified by ORBi)
International
0007-1048
1365-2141
Oxford
United Kingdom
[en] Adult ; Blood Transfusion ; Drug Administration Schedule ; Erythropoietin, Recombinant/administration & dosage/therapeutic use ; Female ; Hemoglobins/analysis ; Humans ; Male ; Middle Aged ; Multiple Myeloma/blood/drug therapy/surgery ; Peripheral Blood Stem Cell Transplantation ; Reoperation ; Transplantation, Autologous
[en] We evaluated the ability of recombinant human erythropoietin (rHuEpo) therapy, given before high-dose therapy (HDT), to allow autologous peripheral blood stem cell transplantation (PBSCT) without red blood cell (RBC) transfusions. Eleven multiple myeloma patients underwent tandem HDT and autologous PBSC, receiving 500 U/kg/week rHuEpo from d 30 after initial transplant. Haemoglobin levels were 9.5 +/- 1.1 g/dl and 12.5 +/- 0.9 g/dl at the first and second transplant respectively (P < 0.001). RBC transfusions were required for 10/11 patients for the first transplant versus 1/11 for the second (P < 0.001). To conclude, a short course of rHuEpo therapy before HDT facilitates the performance of an autologous transplant without RBC transfusions.
http://hdl.handle.net/2268/6289
10.1046/j.1365-2141.2003.04556.x

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