[en] The invention relates to a hybrid protein which fuses the sub-unit B of the choleraic toxin with an active sequence of a heterologous antigen with respect to said unit. Said hybrid protein is comprised of a sequence of said sub-unit which extends between the 3rd and 100th amino acid rest of the complete sub-unit B. The heterologous amino acid sequence is used upstream or downstream of the latter. This hybrid protein is usable for vaccination, particularly to help the stabilisation of heterologous antigens in the intestinal environment.
Disciplines :
Biochemistry, biophysics & molecular biology
Inventor :
Lhoir, Cécile
Renard, André
Martial, Joseph ; Université de Liège - ULiège > Département des sciences de la vie > GIGA-R : Biologie et génétique moléculaire
Language :
English
Title (54) :
PROTEINS FOR FUSING THE SUB-UNIT B OF THE CHOLERAIC TOXIN AND HETEROLOGOUS ANTIGEN, AND NUCLEIC ACIDS ENCODING THEM.