Article (Scientific journals)
Chronic varicella-zoster virus skin lesions in patients with human immunodeficiency virus are related to decreased expression of gE and gB
Nikkels, Arjen; Rentier, Bernard; Pierard, Gérald
1997In Journal of Infectious Diseases, 176 (1), p. 261-264
Peer Reviewed verified by ORBi
 

Files


Full Text
Nikkels JID 1997 261.pdf
Publisher postprint (1.26 MB)
Download

All documents in ORBi are protected by a user license.

Send to



Details



Abstract :
[en] The pathogenesis of chronic, verrucous varicella-zoster virus (VZV) cutaneous lesions in human immunodeficiency virus (HIV)-infected persons is unknown. It has been hypothesized that these lesions are due to an altered pattern of virus gene expression. Immediate early and late (L) gene expression in five chronic verrucous VZV lesions, four full-blown herpes zoster vesicular lesions in HIV-infected persons, and eight vesicular herpes zoster lesions in immunocompetent individuals was semiquantitatively assessed immunohistochemically using specific antibodies to the IE63, gE (L), and gB (L) proteins. All patients had evidence of IE63 expression in keratinocytes; however, gE expression was either weak or absent in keratinocytes of three verrucous lesions, and gB was either weak or absent in two. These results suggest that chronic VZV skin lesions are associated with diminished gE and gB expression. It is inferred that the VZV behavior in keratinocytes may vary from a latency-like state to a fully developed, productive infection.
Disciplines :
Immunology & infectious disease
Author, co-author :
Nikkels, Arjen ;  Université de Liège - ULiège > Dermatologie
Rentier, Bernard  ;  Université de Liège - ULiège > Services administratifs généraux > Recteur - GIGA-R : Virologie - Immunologie
Pierard, Gérald ;  Université de Liège - ULiège > Dermatopathologie
Language :
English
Title :
Chronic varicella-zoster virus skin lesions in patients with human immunodeficiency virus are related to decreased expression of gE and gB
Publication date :
July 1997
Journal title :
Journal of Infectious Diseases
ISSN :
0022-1899
eISSN :
1537-6613
Publisher :
University of Chicago Press
Volume :
176
Issue :
1
Pages :
261-264
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 16 February 2009

Statistics


Number of views
93 (5 by ULiège)
Number of downloads
126 (2 by ULiège)

Scopus citations®
 
31
Scopus citations®
without self-citations
20
OpenCitations
 
27

Bibliography


Similar publications



Contact ORBi