Article (Scientific journals)
Combined study of cerebral glucose metabolism and [11C] methionine accumulation in probable Alzheimer's disease using positron emission tomography
Salmon, Eric; Grégoire, M. C.; Delfiore, Guy et al.
1996In Journal of Cerebral Blood Flow and Metabolism, 16 (3), p. 399-408
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Keywords :
Alzheimer's disease; Positron emission tomography; Fluorine-18-fluorodeoxyglucose; L-(methyl-carbon-11)methionine
Abstract :
[en] There is a characteristic decrease in glucose metabolism in associative frontal and temporo-parietal cortices of patients suffering from Alzheimer's disease (AD). The decrease in metabolism might result from local neuronal loss or from a decrease of synaptic activity. We measured in vivo [11C]methionine accumulation into proteins with positron emission tomography (PET) to assess cortical tissue loss in AD. Both global regional activity and compartmental analysis were used to express [11C]methionine accumulation into brain tissue. Glucose metabolism was measures with [18F]fluorodeoxyglucose and autoradiographic method. Combined studies were performed in 10 patients with probable AD, compared to age-matched healthy volunteers. There was a significant 45% decrease of temporo-parietal glucose metabolism in patients with AD, and frontal metabolism was lowered in most patients. Temporo-parietal metabolism correlated to dementia severity. [11C]methionine incorporation into temporo-parietal and frontal cortices was not significantly decreased in AD. There was no correlation with clinical symptoms. Data suggest that regional tissue loss, assessed by the decrease of [11C]methionine accumulation, is not sufficient to explain cortical glucose hypometabolism, which reflects, rather, reduced synaptic connectivity.
Disciplines :
Neurosciences & behavior
Author, co-author :
Salmon, Eric  ;  Université de Liège - ULiège > Département des sciences cliniques > Neuroimagerie des troubles de la mémoire et révalid. cogn.
Grégoire, M. C.
Delfiore, Guy
Lemaire, Christian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Degueldre, Christian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Franck, Georges ;  Université de Liège - ULiège > Relations académiques et scientifiques (Médecine)
Comar, D.
Language :
English
Title :
Combined study of cerebral glucose metabolism and [11C] methionine accumulation in probable Alzheimer's disease using positron emission tomography
Publication date :
May 1996
Journal title :
Journal of Cerebral Blood Flow and Metabolism
ISSN :
0271-678X
eISSN :
1559-7016
Publisher :
Nature Publishing Group
Volume :
16
Issue :
3
Pages :
399-408
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
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