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Diselenide Derivative, Potential Successor of Ebselen with High Antioxidant Activity: Assessment on in vitro Models
Mareque-Faez, Juan; Deby, Carol; Lamy, Maurice et al.
2008In Resource-Full Chemistry
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Keywords :
Diselenide; Ebselen; Antioxidant; myeloperoxidase (MPO) activity; Glutathione peroxidase (GPx); Reactive Oxygen Species (ROS)
Abstract :
[en] Oxidative stress plays a key role in several pathophysiological events, including the attack of DNA, cell membrane damage and signaling pathways disruption. The harmful effect of oxidant stress has been attributed to a high production of reactive oxygen species (ROS) followed by a depletion of antioxidant enzymes, glutathione peroxidase (GPx), a mammalian selenoenzyme which functions as a catalytic antioxidant, has been described to protect various organisms against oxidative stress. In the past two decades, the design of small weight molecules such as ebselen (PZ 51, 2-phenyl-1,2-benzoisoselenazol-3(2H)-one), has renewed the interest of synthetic analogues able to mimic the GPx activity. From four in vitro in vitro models, we previously showed that ebselen and some of its analogues (compounds 1, 2, 3 and 4) not only behaved at various degrees as GPx-like mimics but also as antioxidants especially for diselenide derivative (3). The present study deals with the antioxidant effect of diselenide derivative (3) versus ebselen on cellular model and the enzyme myeloperoxidase (MPO) activity using the in vitro systems. Derivative (3) has been chosen because of its interesting antioxidant profile in cell-free systems.
Disciplines :
Chemistry
Author, co-author :
Mareque-Faez, Juan
Deby, Carol
Lamy, Maurice ;  Université de Liège - ULiège > Anesthésie et réanimation
Deby-Dupont, Ginette
Serteyn, Didier  ;  Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Mouithys-Mickalad, Ange ;  Université de Liège - ULiège > Centre de l'oxygène : Recherche et développement (C.O.R.D.)
Language :
English
Title :
Diselenide Derivative, Potential Successor of Ebselen with High Antioxidant Activity: Assessment on in vitro Models
Publication date :
24 May 2008
Event name :
91st Canadian Chemistry Conference and Exhibition
Event organizer :
Canadian Society for Chemistry
Event place :
Edmonton, United States - California
Event date :
du 24 au 28 mai 2008
Audience :
International
Main work title :
Resource-Full Chemistry
ISBN/EAN :
0-921763-22-9
Pages :
360 (OR1)
Peer reviewed :
Peer reviewed
Additional URL :
Available on ORBi :
since 10 June 2010

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