Reference : Cyclosporin C Is the Main Antifungal Compound Produced by Acremonium Luzulae
Scientific journals : Article
Life sciences : Microbiology
Cyclosporin C Is the Main Antifungal Compound Produced by Acremonium Luzulae
Moussaif, M. [> > > >]
Jacques, Philippe mailto [Université de Liège > Agronomie, Bio-ingénierie et Chimie (AgroBioChem) > Bio-industries >]
Schaarwachter, P. [> > > >]
Budzikiewicz, H. [> > > >]
Thonart, Philippe mailto [Université de Liège - ULiège > > Gembloux Agro-Bio Tech - Biochimie et microbiologie industrielles >]
Applied and Environmental Microbiology
Yes (verified by ORBi)
[en] A strain of Acremonium luzulae (Fuckel) W. Gams was selected in screening new microorganisms for biological control of fruit postharvest diseases, especially gray and blue mold diseases on apples and strawberries. This strain manifests a very strong activity against a large number of phytopathogenic fungi. In this work, the product responsible for this antifungal activity was isolated from modified Sabouraud dextrose broth cultures of A. luzulae. It was purified to homogeneity by reverse-phase column chromatography. On the basis of UV, infrared, and 1H and 13C nuclear magnetic resonance spectra, mass spectral analysis, and the amino acid composition of the acid hydrolysates, the antibiotic was determined to be cyclosporin C. Cyclosporin C showed a broad-spectrum activity against filamentous phytopathogenic fungi but no activity against bacteria or yeasts. Its antifungal activity is only fungistatic. In contrast to Tolypocladium inflatum, another cyclosporin-producing strain, A. luzulae, did not produce additional cyclosporins. This was confirmed by in vivo-directed biosynthesis.

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