[en] Cardiomyoplasty is a new surgical procedure using transformed skeletal muscle to reinforce or substitute for the myocardium. For the purpose of studying surgical technique and investigating basic questions, we have developed a model of reinforcement cardiomyoplasty. Herein, we describe anesthetic management, surgical technique, and the technique for iterative transthoracic biopsies. This model has proven to be valuable in several long-term studies involving more than 30 goats. Preliminary data to ascertain the efficacy of the proposed technique are provided.
Disciplines :
Surgery
Author, co-author :
Radermecker, M. A.
Fourny, J.
Bonnet, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Urologie
Philippart, C.
Serteyn, Didier ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Limet, Raymond ; Université de Liège - ULiège > Département des sciences cliniques > Chirurgie cardio-vasculaire et thoracique
Language :
English
Title :
Surgical Technique for Cardiomyoplasty and Iterative Transthoracic Biopsies in an Experimental Goat Model
Carpentier A, Chachques JC: Myocardial substitution with a stimulated skeletal muscle. First successful clinical case. Lancet 1985;8440: 1267.
Chachques JC, Grandjean P, Schwartz K, Mihaileanu S, Fardeau M, Swyngliedauw B, Fontaliran F, Romero N, Wisnewsky C, Perier P, Chauvaud S, Bourgeois I, Carpentier A: Effects of latissimus dorsi dynamic cardiomyoplasty on ventricular function. Circulation 1988;78/3: 203-216.
Magovern GJ, Heckler FR, Park SB, Christlicb IY, Kao RL, Benckart DH, Tullis G, Rozar E, Liebler GA, Burkholder JA, Malier TD: Paced latissimus dorsi used for dynamic cardiomyoplasty of left ventricular aneurysm. Ann Thorac Surg 1987; 44:379-388.
Pette D, Müller W, Leisner E, Vrbova G: Time dependent effects on contractile properties, fibre population. myosin light chains and enzymes of energy metabolism in intermittently and continuously stimulated fast twitch muscles of myosin isoforms. J Cell Biol 1985;100:161-174.
Salmons S, Henriksson J: The adaptative response of skeletal muscle to increase use. Muscle Nerve 1981;4: 94-105.
Grandjean PA, Herpers L, Smits K, Bourgeois I, Chachques JC, Carpentier A: Implantable electronics and leads for muscular cardiac assistance; in Chiu RCJ (ed): Biomedical Cardiac Assist. New York. Futura Publishing. 1986, pp 103-114.
Kao RL, Christlieb IY, Magovern GJ, Park SB: The importance of skeletal muscle fiber orientation for dynamic cardiomyoplasty. J Thorac Cardiovasc Surg 1990;92:134-140.
