Article (Scientific journals)
Diffuse dermal angiomatosis: A previously undescribed pattern of immunoglobulin and complement deposits in two cases.
Quatresooz, Pascale; Fumal, Isabelle; Willemaers, Valentine et al.
2006In American Journal of Dermatopathology, 28 (2), p. 150-4
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Keywords :
Abdomen; Adult; Angiomatosis/immunology/pathology; Basement Membrane/immunology/pathology; Breast Diseases/immunology/pathology; Collagen/analysis; Complement System Proteins/analysis; Dermis/immunology/pathology; Endothelial Cells/immunology/pathology; Endothelium, Vascular/immunology/pathology; Epidermis/immunology/pathology; Female; Humans; Immunoglobulin A/analysis; Immunoglobulin M/analysis; Middle Aged; Paraproteinemias/diagnosis; Skin Diseases, Vascular/immunology/pathology; Skin Ulcer/immunology/pathology
Abstract :
[en] Two cases of diffuse dermal angiomatosis are reported in middle-aged women. This rare disease of unknown origin is characterized by increased dermal angiomatosis and ulceration. The clinical and histologic presentations of the presently reported lesions were typical for this disorder. Endothelial cells exhibited a normal immunophenotype. The perivascular basement membranes showed a distribution of collagen alpha chains typical for blood vessels, but not for lymphatics. Immunohistochemistry revealed other undescribed features. At the site of the clinical lesions, linear and granular deposits of immunoglobulins A and M, and complement were found around the vessels and at the dermal-epidermal junction. The same deposits were also found restricted to the dermal-epidermal junction in the peripheral clinically intact skin. No serological signs of auto-immune disorder were detected in one patient. A monoclonal gammopathy was disclosed in the other patient. A pattern of immunoreactant deposits similar to that disclosed in the two patients was not found in the control specimens, and has not been described so far in other types of vascular hyperplasia and neoplasia. A pathogenic role of these deposits is unsettled and should be further explored.
Disciplines :
Dermatology
Author, co-author :
Quatresooz, Pascale  ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Fumal, Isabelle;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Willemaers, Valentine;  Centre Hospitalier Régionale de la Citadelle (Liège) - CHR CITADELLE > Dermatologie
Cornil, France;  Centre Hospitalier Régionale de la Citadelle (Liège) - CHR CITADELLE > Dermatologie
Pierard, Gérald ;  Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Language :
English
Title :
Diffuse dermal angiomatosis: A previously undescribed pattern of immunoglobulin and complement deposits in two cases.
Publication date :
2006
Journal title :
American Journal of Dermatopathology
ISSN :
0193-1091
eISSN :
1533-0311
Publisher :
Lippincott Williams & Wilkins, Philadelphia, United States - Pennsylvania
Volume :
28
Issue :
2
Pages :
150-4
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 11 February 2009

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