G-quadruplexes in telomeric repeats are conserved in a solvent-free environment

Baker, Erin Shammel; Bernstein, Summer L; Gabelica, Valérie; De Pauw, Edwin; Bowers, Michael T

doi:10.1016/j.ijms.2006.03.016

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G-quadruplexes in telomeric repeats are conserved in a solvent-free environment

Baker, Erin Shammel; Bernstein, Summer L; Gabelica, Valérie et al.

2006 • In International Journal of Mass Spectrometry, 253 (3), p. 225-237

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https://hdl.handle.net/2268/605

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10.1016/j.ijms.2006.03.016

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Keywords :

ion mobility; G-quadruplexes; DNA; mass spectrometry

Abstract :

[en] The structural properties of G-quadruplex forming sequences. such as the human telomeric repeat d(T(2)AG(3))(n), are of great interest due to their role in cancer and cellular aging. To determine if G-quadruplexes are present in a solvent-free environment. different lengths of the telomeric repeat d(T(2)AG(3))(n) (where n = 1, 2, 4 and 6) and dTG(4)T were investigated with mass specteometry, ion mobility and molecular dynamics calculations. Nano-ESI-MS illustrated quadruples stoichiometries compatible with G-quadruplex Structure.; for each sequence, with dT(2)AG(3) and dTG(4)T forming 4-strand complexes with two and three NH4+ adducts. d(T(2)AG(3))(2) a 2-strand complex. and d(T(2)AG(3))(4) and d(T(2)AG(3))(6) remaining single-stranded. Experimental cross sections were obtained for all species using ion mobility method.,. In all case.,. these could be quantitatively matched to model cross sections with specific strand orientations (parallel/antiparallel) and structures. For each species, the solvent-free structures agreed with the solution CD measurements, but the ion mobility/modeling procedure often gave Much more detailed structural information. (C) 2006 Elsevier B.V. All rights reserved.

Research Center/Unit :

CART - Centre Interfacultaire d'Analyse des Résidus en Traces - ULiège

Disciplines :

Chemistry

Author, co-author :

Baker, Erin Shammel; University of California Santa Barbara - UCSB > Department of Chemistry and Biochemistry

Bernstein, Summer L; University of California Santa Barbara - UCSB > Department of Chemistry and Biochemistry

Gabelica, Valérie ; Université de Liège - ULiège > Département de Chimie (Sciences) > Chimie physique, spectrométrie de masse

De Pauw, Edwin ; Université de Liège - ULiège > Département de Chimie (Sciences) > Chimie physique, spectrométrie de masse

Bowers, Michael T; University of California Santa Barbara - UCSB > Department of Chemistry and Biochemistry

Language :

English

Title :

G-quadruplexes in telomeric repeats are conserved in a solvent-free environment

Publication date :

2006

Journal title :

International Journal of Mass Spectrometry

ISSN :

1387-3806

Publisher :

Elsevier Science, Amsterdam, Netherlands

Volume :

253

Issue :

Pages :

225-237

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique

Commentary :

This is a postprint author version of an article published as: E.S. Baker, S.L. Bernstein, V. Gabelica, E. De Pauw, M.T. Bowers, " G-Quadruplexes in Telomeric Repeats Are Conserved in a Solvent-Free Environment", Int. J. Mass Spectrom. (2006), 253(3) Special Issue "Solution vs. Gas Phase Biomolecule Structure", 225-237.

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