Article (Scientific journals)
Impact of bone marker feedback on adherence to once monthly ibandronate for osteoporosis among Asian postmenopausal women
Kung, Annie Wai-Chee; Rachman, A Ichramsjah; Adam, MF John et al.
2009In International Journal of Rheumatic Diseases, 12, p. 216-224
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Keywords :
adherence; bone marker; compliance; feedback; ibandronate; osteoporosis
Abstract :
[en] Aim: This study assesses the impact of serum carboxy-terminal collagen crosslinks (CTX) bone marker feedback (BMF) on adherence to ibandronate treatment in Asian postmenopausal women with osteoporosis. Methods: This was a 12-month (6-monthly phased), randomized, prospective, open-label, multi-center study conducted in 596 (of 628 enrolled) postmenopausal women with osteoporosis (£ 85 years old) who were naı¨ve, lapsed, or current bisphosphonate users. Patients were randomized into two arms: serum CTX BMF at 3 months versus no-BMF. Once-monthly 150 mg ibandronate tablet was administered for 12 months and adherence to therapy was assessed at 6 and 12 months. In addition, patient satisfaction and safety of ibandronate treatment were also assessed. Results: Serum CTX BMF at 3 months showed no impact on adherence. The proportions of adherent patients were comparable in the BMF versus no-BMF arms (92.6% vs. 96.0%, P = 0.16); overall, serum CTX levels were similar for adherent and non-adherent patients. However, BMF patients felt more informed about their osteoporosis (P < 0.001) and more satisfied (P < 0.01) than no-BMF patients. Conclusions: The Asian postmenopausal osteoporosis patients in this study had a high adherence rate to once-monthly ibandronate therapy. Use of serum CTX BMF had no further impact on increasing adherence, but increased treatment satisfaction.
Disciplines :
Rheumatology
Author, co-author :
Kung, Annie Wai-Chee
Rachman, A Ichramsjah
Adam, MF John
Roeshadi, Djoko
Torralba, Tito
Navarra, Sandra
Gamilla, Zayda
Cañete, Arthur
de la Rosa, Miles
Tsai, KehSung
Lin, Hsiao-Yi
Soong, Yung Kuei
Lan, Joung-Liang
Hsu, Horng-Chaung
Tu, Shih-Te
Lin, Ruey-Mo
Yuktanandana, Pongsak
Songpatanasilp, Thawee
Ngarmukos, Srihatach
Soontrapa, Sugree
Soontrapa, Suppasin
Rojanasthien, Sattaya
Luevitoonvechkij, Sirichai
Leerapan, Taninnit
Albert, Adelin  ;  Université de Liège - ULiège > Département des sciences de la santé publique > Informatique médicale et biostatistique - Département de mathématique
Vanbelle, Sophie ;  Université de Liège - ULiège > Département de mathématique > Département de mathématique
More authors (16 more) Less
Language :
English
Title :
Impact of bone marker feedback on adherence to once monthly ibandronate for osteoporosis among Asian postmenopausal women
Publication date :
2009
Journal title :
International Journal of Rheumatic Diseases
ISSN :
1756-1841
eISSN :
1756-185X
Publisher :
Blackwell, Oxford, United Kingdom
Volume :
12
Pages :
216-224
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
the BonAdAsia study group
Available on ORBi :
since 01 June 2010

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