Article (Scientific journals)
Abdominal aortic calcification in dialysis patients: results
Honkanen, Eero; Kauppila, Leena; Wikström, Björn et al.
2008In Nephrology Dialysis Transplantation, 12, p. 4009-4015
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Keywords :
Calcification; Cardiovascular disease; Chronic kidney disease; Dialysis; Lateral lumbar radiography
Abstract :
[en] Abstract Background. Patients with chronic kidney disease stage 5 have a high prevalence of vascular calcification, but the specific anatomical distribution and severity of abdominal aortic calcification (AAC), in contrast to coronary calcification, is less well documented. AAC may be recorded using plain radiographs. The present report is an analysis of baseline data on AAC in patients enrolled in the CORD (Calcification Outcome in Renal Disease) study. Methods. A total of 47 centres in six European countries participated in this cross-sectional study. Inclusion criteria were age ≥18 years and duration of dialysis ≥3 months. Lateral lumbar radiography of the abdominal aortawas used to determine the overall AAC score, which is related to the severity of calcific deposits at lumbar vertebral segments L1–L4. The reliability of the method was tested by double reading of 64 radiographs (coefficient of correlation 0.9). Results. A lateral lumbar radiograph was obtained in 933 patients. Calcification (AAC score ≥ 1) was present in 81% of the patients; its severity increased significantly from L1 to L4 (P < 0.0001) and affected all of these segments in 51% of patients. Independent predictors for the presence and severity of calcification were age (odds ratio [OR] 1.103/year; P < 0.0001), duration of dialysis (OR 1.110/year; P = 0.002) and history of cardiovascular disease (OR 3.247; P < 0.0001). Conclusions. AAC detected by lateral lumbar radiograph is associated with several risk factors of uraemic calcification. This semi-quantitative method is more widely available and less expensive than the current procedures for studying calcification and could formpart of a pre-transplantworkup and cardiovascular risk stratification.
Disciplines :
General & internal medicine
Urology & nephrology
Author, co-author :
Honkanen, Eero;  University of Helsinki - Finland > Medicine > Division of Nephrology
Kauppila, Leena;  Helskinki University Central Hospital - Espoo - Finland > Rehabilitation
Wikström, Björn;  Uppsala University Hospital - Uppsala - Sweden > Nephrology
Rensma, Pieter L.;  St. Elisabeth Hospital Tilburg - Tilburg - The Netherlands > Internal Medicine
Krzesinski, Jean-Marie ;  Université de Liège - ULiège > Département des sciences cliniques > Néphrologie
Aasarod, Knut;  Trondheim University Hospital - Tronheim - Norway > Medicine
Verbeke, Francis;  Universitair Ziekenhuis Gent - UZ > Nephrology
Jensen, Per Bruno;  Odense Universiteitshospital - OUH - Denmark
Mattelaer, Pierre;  Genzyme A/S - Cophenhagen - Danmark
Volck, Birgitte;  Genzyme A/S - Coppenhagen - Denmark
Language :
English
Title :
Abdominal aortic calcification in dialysis patients: results
Publication date :
23 December 2008
Journal title :
Nephrology Dialysis Transplantation
ISSN :
0931-0509
eISSN :
1460-2385
Publisher :
Oxford University Press, Oxford, United Kingdom
Volume :
12
Pages :
4009-4015
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 10 February 2009

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