Reference : Randomized controlled study of the influence of two low estrogen dose oral contracept...
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
Human health sciences : Reproductive medicine (gynecology, andrology, obstetrics)
Randomized controlled study of the influence of two low estrogen dose oral contraceptives containing gestodene or desogestrel on carbohydrate metabolism.
Ludicke, Frank [> > > >]
Gaspard, Ulysse mailto [Centre Hospitalier Universitaire de Liège - CHU > > Gynécologie-Obstétrique >]
Demeyer, Fabienne [Université de Liège - ULiège > > Gynécologie-Obstétrique-Sénologie >]
Scheen, André mailto [Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale >]
Lefebvre, Pierre [Centre Hospitalier Universitaire de Liège - CHU > > Diabétologie,nutrition, maladies métaboliques >]
Yes (verified by ORBi)
New York
[en] Adult ; Blood Glucose/analysis ; C-Peptide/blood ; Contraceptives, Oral, Combined/administration & dosage/adverse effects ; Desogestrel/administration & dosage/adverse effects ; Ethinyl Estradiol/administration & dosage/adverse effects ; Fasting ; Female ; Glucose Tolerance Test ; Humans ; Insulin/blood ; Norpregnenes/administration & dosage/adverse effects ; Uterine Hemorrhage
[en] This study compared the impact on carbohydrate metabolism of two combinedoral contraceptives (COCs). This open-label, single-center trial enrolled participants for a total of 15 cycles. Thirty-six women were randomized to receive either 20 microg ethinyl estradiol (EE) and 75 microg gestodene (GSD) or 20 microg ethinyl estradiol and 150 microg desogestrel (DSG) daily for 21 days out of 28. A glucose tolerance test was performed at baseline and cycles 6 and 13. The area under the curve (AUC) for glucose increased in both study groups. The change was statistically significant (p = 0.036) for the 20 EE/75 GSD group at cycle 6 versus baseline. Fasting blood glucose at cycle 13 was significantly (p < 0.01) higher for both treatment groups compared to baseline. No changes were found for fasting insulin and fasting C-peptide levels or for the AUCs of insulin or C-peptide. Both regimens were well tolerated. Gestodene and desogestrel in combination with 20-microg ethinyl estradiol induce similar changes in carbohydrate metabolism which are smaller than those described earlier for COCs containing higher estrogen doses or more androgenic progestins such as levonorgestrel.
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Copyright 2002 Elsevier Science Inc.

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