[en] Dermatopathology is a tool using the microscopic examination for diagnosing cutaneous diseases. The frontiers of its field of interest were extended by exploring the physiopathology of skin functional properties. An example is provided by the evaluation of alterations of skin suppleness in various connective tissue disorders. This approach takes profit from both conventional histology and histochemistry. Immunohistology targeting dermal dendrocytes reveals their various shapes reflecting the modifications in tensegrity under the control of mechanobiology. The latter property is an indicator of the evolution and severity of the connective tissue changes. Electron microscopy is also very instructive in this field. The in vivo examination by dermoscopy highlights a similar mechanism involving the melanocytes. From an engineering point of view, the skin and subcutaneous tissue represent an integrated load-transmitting structure. It is subjected to intrinsic and environmental influences. Some models were offered to explain how skin withstands and transmits loads through deforming appropriately or abnormally according to disorders of the connective tissue structure. We report a brief review of the principles of interpretation of the measurements of the skin biomechanical properties, and the histological presentations of mechanobiology. The applications of such investigations are summarized in the Ehlers-Danlos syndrome, inguinal hernias, gravitational syndrome, diabetes, scleroderma, hemodialysed patients, in case of growth hormone administration and during climacteric.
Disciplines :
Dermatology
Author, co-author :
Pierard, Gérald ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Pierard, Claudine ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Hermanns-Lê, Trinh ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Quatresooz, Pascale ; Centre Hospitalier Universitaire de Liège - CHU > Dermatopathologie
Language :
French
Title :
Peaufiner la dermatopathologie fonctionnelle, la dermometrologie et la mecanobiologie.
Alternative titles :
[en] Polishing up functional dermatopathology, dermometrology and mechanobiology
Publication date :
2007
Journal title :
Revue Médicale de Liège
ISSN :
0370-629X
eISSN :
2566-1566
Publisher :
Université de Liège. Revue Médicale de Liège, Liège, Belgium
Quatresooz P, Piérard GE. - Comment j'explore... une pathologie d'aspect microscopique cutané apparemment sain. Rev Med Liège, 2005, 60, 117-120.
Uhoda E, Paye M, Piérard GE. - Actualités en ingénierie cutanée. Editions Eska, Paris, 2006, pp 1-302.
Piérard GE, Henry F. - Essai de classement catégoriel des propriétés biomécaniques de la peau. Evaluations par la méthode de succion. Nouv Dermatol, 1995, 14, 630-636.
Piérard GE, Masson P, Rodrigues L, et al. - EEMCO guidance to the in vivo assessment of tensile functional properties of the skin. Part 1: Relevance to the structures and ageing of the skin and subcutaneous tissues. Skin Pharmacol Appl Skin Physiol, 1999, 12, 352-362.
Hermanns-Lê T, Jonlet F, Scheen A, Piérard GE. - Age-and body mass index-related changes in cutaneous shear wave velocity. Exp Gerontol, 2001, 36, 363-372.
Nizet JL, Piérard-Franchimont C, Piérard GE. - Influence of body posture and gravitational forces on shear wave propagation in the skin. Dermatology, 2001, 202, 177-180.
Piérard GE, Kort R, Letawe C, et al. - Biomechanical assessment of photodamage. Derivation of a cutaneous extrinsic ageing score. Skin Res Technol, 1995, 1, 17-20.
Henry F, Piérard-Franchimont C, Cauwenbergh G, Piérard GE. - Age-related changes in facial skin contours and rheology. J Am Geriatr Soc, 1997, 45, 220-222.
Henry F, Piérard-Franchimont C, Pans A, Piérard GE. - Striae distensae of pregnancy. An in vivo biomechanical evaluation. Int J Dermatol, 1997, 36, 506-508.
Piérard-Franchimont C, Henry F, Piérard GE. - Mechanical properties of primary anetoderma in a child. Skin Res Technol, 1997, 2, 81-83.
Piérard-Franchimont C, Letawe C, Fumal I, et al. - Gravitational syndrome and tensile properties of skin in the elderly. Dermatology, 1998, 197, 317-320.
Piérard GE, Nizet JL, Adant JP, et al. - Tensile properties of relaxed excised skin exhibiting striae distensae. J Med Eng Technol, 1999, 23, 69-72.
Fournier R, Piérard GE. - Skin tensile strength modulation by compressive garments in burn patients. A pilot study. J Med Eng Technol, 2000, 24, 277-280.
Piérard GE, Piérard-Franchimont C, Vanderplaetsen S, et al. - Relationships between bone mass density and tensile strength of the skin in women. Eur J Clin Invest, 2001, 31, 731-735.
Uhoda I, Faska N, Robert C, et al. - Split face study of the cutaneous tensile effect of a 2-dimethylaminoethanol (deanol) gel. Skin Res Technol, 2002, 8, 164-167.
Hermanns-Lê T, Uhoda I, Smitz S, Piérard GE. - Skin tensile properties revisited during ageing. Where now, where next ? J Cosmet Dermatol, 2004, 3, 35-40.
Quatresooz P, Piérard-Franchimont C, Kharfi M, et al. - Skin in maturity. The endocrine and neuroendocrine pathways. Int J Cosmet Sci, 2007, 29, 1-6.
Hermanns-Lê T, Piérard GE. - Factor XIIIa-positive dendrocyte rarefaction in Ehlers-Danlos syndrome, classic type. Am J Dermatopathol, 2001, 23, 427-430.
Hermanns-Lê T, Uhoda I, Piérard-Franchimont C, Piérard GE. - Factor XIIIa-positive dermal dendrocytes and shear wave propagation in human skin. Eur J Clin Invest, 2002, 32, 847-851.
Quatresooz P, Hermanns-Lê T, Ciccarelli A, et al. - Tensegrity and type I dermal dendrocytes in acromegaly. Eur J Clin Invest, 2005, 35, 133-139.
Quatresooz P, Xhauflaire-Uhoda E, Piérard-Franchimont C, Piérard GE. - Cellulite histopathology and related mechanobiology. Int J Cosmet Sci, 2006, 28, 207-210.
Piérard-Franchimont C, Hermanns JF, Hermanns-Lê T, Piérard GE. - Striae distensae in darker skin types : the influence of melanocyte mechanobiology. J Cosmet Dermatol, 2005, 4, 174-178.
Quatresooz P, Hermanns JF, Paquet P, Piérard GE. - Mechanobiology and force transduction in scars developed in darker skin types. Skin Res Technol, 2006, 12, 279-282.
Hermanns-Lê T, Piérard GE. - The collagen fibril arabesques in connective tissue disorders. Am J Clin Dermatol, 2006, 7, 323-326.
Piérard GE, Piérard-Franchimont C, Lapière ChM. - Histopathology aid at the diagnosis of the Ehlers-Danlos syndrome gravis and mitis types. Int J Dermatol, 1983, 22, 300-304.
Henry F, Goffin V, Piérard-Franchimont C, Piérard GE. - Mechanical properties of skin in Ehlers-Danlos syndrome, types I, II and III. Ped Dermatol, 1996, 13, 464-467.
Hermanns-Lê T, Piérard GE, Quatresooz P. - Ehlers-Danlos-like dermal abnormalities in women with recurrent preterm premature ruptures of the fetal membranes. Am J Dermatopathol, 2005, 27, 407-410.
Flagothier C, Goffin V, Hermanns-Lê T, et al. - A four-generation Ehlers-Danlos syndrome with vascular dissections. Skin ultrastructure and biomechanical properties. J Med Eng Technol, EPub 29-03-06.
Hermanns-Lê T, Piérard GE. - Ultrastructural alterations of elastic fibres and other dermal components in Ehlers-Danlos syndrome of the hypermobile type. Am J Dermatopathol, sous presse.
Pans A, Piérard GE, Albert A, Desaive C. - Biomechanical assessment of the transversal is fascia and rectus abdominis aponeurosis in inguinal herniation. Preliminary results. Hernia, 1997, 1, 27-30.
Pans A, Piérard GE, Albert A, Desaive C. - Adult groin hernias. New insight into their biomechanical characteristics. Eur J Clin Invest, 1997, 27, 863-868.
Piérard GE, Letawe C, Dowlati A, Piérard-Franchimont C. - Effect of hormone replacement therapy for menopause on the mechanical properties of skin. J Am Geriatr Soc, 1995, 43, 662-665.
Piérard GE, Henry F, Piérard-Franchimont C. - Comparative effect of short-term topical tretinoin and glycolic acid on mechanical properties of photodamaged facial skin in HRT-treated menopausal women. Maturitas, 1996, 23, 273-277.
Piérard-Franchimont C, Cornil F, Dehavay J, et al. - Climacteric skin ageing of the face. A prospective longitudinal intent-to-treat trial on the effect of oral hormone replacement therapy. Maturitas, 1999, 32, 87-93.
Piérard GE, Vanderplaetsen S, Piérard-Franchimont C. - Comparative effect of hormone replacement therapy on bone mass density and skin tensile properties. Maturitas, 2001, 40, 221-227.
Deleixhe-Mauhin F, Piérard-Franchimont C, Rorive G, Piérard GE. - Influence of chronic haemodialysis on the mechanical properties of skin. Clin Exp Dermatol, 1994, 19, 130-133.
Uhoda I, Petit L, Krzesinski JM, et al. - Effect of haemodialysis on acoustic shear wave propagation in the skin. Dermatology, 2004, 209, 95-100.
Nikkels-Tassoudji N, Henry F, Letawe C, et al. - Mechanical properties of the diabetic waxy skin. Dermatology, 1996, 192, 19-22.
Piérard-Franchimont C, Nikkels-Tassoudji N, Lefebvre P, Piérard GE. - Subclinical skin stiffening in adults suffering from type 1 diabetes mellitus. A comparison with Raynaud's syndrome. J Med Eng Technol, 1998, 22, 206-210.
Piérard-Franchimont C, Henry F, Crielaard JM, Piérard GE. - Mechanical properties of skin in recombinant human growth factor abusers among adult body builders. Dermatology, 1996, 192, 389-392.
Piérard GE. - Histological and rheological grading of cutaneous sclerosis in scleroderma. Dermatologica, 1989, 179, 18-20.
Nikkels-Tassoudji N, Henry F, Piérard-Franchimont C, Piérard GE. - Computerized evaluation of skin stiffening in scleroderma. Eur J Clin Invest, 1996, 26, 457-460.
Quatresooz P, Paquet P, Piérard-Franchimont C, Piérard GE. - Comment j'explore... la piste toxique revisitée des sclérodermies. Rev Med Liège, 2007, 62, 170-174.
