[en] Pregnancy in cattle and sheep can be diagnosed by the presence of a conceptus-derived antigen in maternal serum that is secreted by trophoblast and placental tissue primarily as an acidic component of Mr 67,000. Molecular cloning of its cDNA reveals that the antigen belongs to the aspartic proteinase family and has greater than 50% amino acid sequence identity to pepsin, cathepsin D, and cathepsin E. The inferred sequences of the ovine and bovine polypeptides show approximately 73% identity to each other. Critical amino acid substitutions at the active site regions suggest that both proteins are enzymatically inactive. The antigen is a product of trophoblast binucleate cells that invade maternal endometrium at implantation sites.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Xie, Sancai; University of Missouri - MU > Animal Science
Low, Boon G.; University of Missouri - MU > Animal Sciences
Nagel, Robert J.; University of Missouri - MU > Animal Sciences
Kramer, Kyle K.; University of Missouri - MU > Animal Sciences
Anthony, Russel V.; University of Missouri - MU > Animal Sciences
Zoli, André Pagnah; Université de Liège - ULiège > Faculté de Médecine Vétérinaire
Beckers, Jean-François ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction
Roberts, R. Michael; University of Missouri - MU > Animal Sciences and Biochemistry
Language :
English
Title :
Identification of the major pregnancy-specific antigens of cattle and sheep as inactive members of the aspartic proteinase family
Publication date :
November 1991
Journal title :
Proceedings of the National Academy of Sciences of the United States of America
ISSN :
0027-8424
eISSN :
1091-6490
Publisher :
National Academy of Sciences, Washington, United States - District of Columbia
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