Are Antibodies Responsible for a Decreased Superovulatory Response in Goats Which Have Been Treated Repeatedly with Porcine Follicle-Stimulating Hormone ?
[en] Repeated administration of xenogenic gonadotropins in human or animal species may be responsible for antibody production and refractoriness. An experiment was conducted in which goats were treated with porcine FSH (p-FSH) at 6-week intervals for a period of 7 months. A sensitive radioimmunoassay (RIA) was used to detect antibodies to p-FSH in plasma samples taken at short-term intervals during a 7-month period. Antibodies appeared after the first injection, and levels increased following booster injections. A high correlation rate existed between antibody level and superovulatory response. Refractoriness in goats was associated with a high level of antibodies.
Research Center/Unit :
Laboratoire d'Endocrinologie et de Physiologie de la Reproduction animale
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Remy, Benoit; Université de Liège - ULiège > Faculté de Médecine vétérinaire
Baril, Gérard; Institut Scientifique de Recherche Agronomique - INRA > Physiologie de la reproduction Nouzilly
Vallet, J. C.; Institut Scientifique de Recherche Agronomique - INRA > Physiologie de la reproduction Nouzilly
Dufour, R.; IFFA Mérieux Lyon France
Chouvet, Claire; IFFA Mérieux Lyon France
Saumande, Jean; Institut Scientifique de Recherche Agronomique - INRA > Physiologie de la reproduction Nouzilly
Chupin, D.; Institut Scientifique de Recherche Agronomique - INRA > Physiologie de la reproduction Nouzilly
Beckers, Jean-François ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie de la reproduction
Language :
English
Title :
Are Antibodies Responsible for a Decreased Superovulatory Response in Goats Which Have Been Treated Repeatedly with Porcine Follicle-Stimulating Hormone ?
Publication date :
September 1991
Journal title :
Theriogenology
ISSN :
0093-691X
eISSN :
1879-3231
Publisher :
Elsevier, New York, United States - New York
Volume :
36
Issue :
3
Pages :
389-99
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
IRSIA - Institut pour l'Encouragement de la Recherche Scientifique dans l'Industrie et l'Agriculture
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