Reference : The epidemiology and genetics of pituitary adenomas.
Scientific journals : Article
Human health sciences : Endocrinology, metabolism & nutrition
The epidemiology and genetics of pituitary adenomas.
Daly, Adrian [Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie >]
Tichomirowa, M. A. [> > > >]
Beckers, Albert mailto [Université de Liège - ULiège > Département des sciences cliniques > Endocrinologie >]
Best Practice and Research. Clinical Endocrinology and Metabolism
Bailliere Tindall
Yes (verified by ORBi)
United Kingdom
[en] Adenoma/epidemiology/genetics/pathology ; Autopsy ; Carney Complex/epidemiology/genetics ; Humans ; Multiple Endocrine Neoplasia/complications/epidemiology/genetics ; Pituitary Neoplasms/epidemiology/genetics/pathology ; Population ; Registries
[en] According to data derived from autopsy and radiological imaging series, pituitary tumours occur very commonly in the general population; however, most of these tumours are incidental findings with no obvious clinical impact. The historical data on the prevalence of pituitary adenomas in the clinical setting are scant and point to such tumours being relatively rare. Recent studies have shown that the prevalence of clinically relevant pituitary adenomas is 3-5 times higher than previously reported, which adds impetus to research into the aetiology of these tumours. Although the majority of pituitary adenomas are sporadic, approximately 5% of all cases occur in a familial setting and over half of these are due to Multiple Endocrine Neoplasia Type 1 (MEN-1) and Carney's Complex (CNC) disorders. Since the late 1990 s, we have described non-MEN1/CNC familial pituitary tumours that include all tumour phenotypes as a condition termed Familial Isolated Pituitary Adenomas (FIPAs). The clinical characteristics of the FIPAs vary from those sporadic pituitary adenomas, as patients with FIPAs have a younger age at diagnosis and larger tumours. About 15% of the FIPA patients have mutations in the aryl hydrocarbon receptor-interacting protein gene (AIP), which indicates that the FIPA may have a diverse genetic pathophysiology.
Researchers ; Professionals

File(s) associated to this reference

Fulltext file(s):

Restricted access
epidemio and genetics best practice and research nov09.pdfPublisher postprint306.21 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.