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VALAPODYN: Validated Predictive Dynamic Model of Complex Intracellular Pathways Related to Cell Death and Survival
Depaulis, Antoine; Vafiadaki, Elizabeth; Jackers, Pascale et al.
2007In European Journal of Human Genetics, 15 (Supp 1), p. 307
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Keywords :
cell death; brain diseases; molecular interactions; systems biology; therapeutic targets; genomics; proteomics; bioinformatics; dynamic; microarrays; 2D-DIGE; MALDI/TOF-TOF; regulation; pathways; networks
Abstract :
[en] VALAPODYN is a research network funded by the European Commission (6th Framework Program) which is developing an original systems biology approach focused on the development of multidisciplinary functional genomics related to complex biological processes and cellular networks. The aim is to generate an innovative approach to model the dynamics of molecular interaction networks (MIN) in relation to cell death and survival to detect new therapeutic targets to treat human brain diseases. The project consists of fundamental genomics research which is integrating statistical data analysis with real biological data in order to functionally annotate genes and proteins. Specialized genomics and proteomics databases for MIN modeling are being used along with leading microarray and proteomics platform systems to investigate protein-protein interactions and regulation networks. This will help to identify and validate biological targets in complex intracellular pathways to cure multifactorial diseases. Dynamic modeling specifically addresses the systems biology of complex cellular pathways and transcriptional networks. The novel dynamic models will be validated by testing the selected drug targets on innovative in vivo and in vitro models of CNS pathologies. As opposed to most current biological data analysis methods, VALAPODYN develops a dynamic and quantitative analysis method for new therapeutic targets through MIN dynamic models. It will provide a cutting-edge highly accurate in silico tool for identifying novel and effective therapeutic targets in a much faster, more efficient and more economical way than it is possible today. (www.valapodyn.eu).
Research center :
CART - Centre Interfacultaire d'Analyse des Résidus en Traces - ULiège
Disciplines :
Chemistry
Engineering, computing & technology: Multidisciplinary, general & others
Neurology
Pharmacy, pharmacology & toxicology
Biochemistry, biophysics & molecular biology
Biotechnology
Genetics & genetic processes
Author, co-author :
Depaulis, Antoine;  Institut National de la Sante et de la Recherche Medicale, Grenoble, France
Vafiadaki, Elizabeth;  Foundation for Biomedical Research, Academy of Athens, Athens, Greece
Jackers, Pascale ;  Université de Liège - ULiège > Center for Analytical Research and Technology (CART)
Arvanitis, D. A.;  Foundation for Biomedical Research, Academy of Athens, Athens, Greece
Kel-Margoulis, Olga;  Biobase, GmbH, Wolfenbuettel, Germany
Wingender, Edgar;  Biobase, GmbH, Wolfenbuettel, Germany
Vujasinovic, Todor;  HELIOS, Paris, France
Greenberg, David;  Hebrew University of Jerusalem, Jerusalem, Israel
Soreq, Hermona;  Hebrew University of Jerusalem, Jerusalem, Israel
De Pauw, Edwin  ;  Université de Liège - ULiège > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.)
Dumas Milne Edwards, Jean-Baptiste;  HELIOS, Paris, France
Sanoudou, Despina;  Foundation for Biomedical Research, Academy of Athens, Athens, Greece
Language :
English
Title :
VALAPODYN: Validated Predictive Dynamic Model of Complex Intracellular Pathways Related to Cell Death and Survival
Publication date :
16 June 2007
Event name :
European Society of Human Genetics Annual Meeting
Event organizer :
Nature Publishing Group npg
Event place :
Nice, France
Event date :
16/06/2007 au 19/06/2007
Audience :
International
Journal title :
European Journal of Human Genetics
ISSN :
1018-4813
eISSN :
1476-5438
Publisher :
Nature Publishing Group, London, United Kingdom
Volume :
15
Issue :
Supp 1
Pages :
307
Peer reviewed :
Peer Reviewed verified by ORBi
Name of the research project :
‘Validated Predictive Dynamic Model of Complex Intracellular Pathways Related to Cell Death and Survival’
Funders :
EU Commission, FP6 (Valapodyn)
Available on ORBi :
since 26 May 2010

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