Reference : VALAPODYN: Validated Predictive Dynamic Model of Complex Intracellular Pathways Relat...
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VALAPODYN: Validated Predictive Dynamic Model of Complex Intracellular Pathways Related to Cell Death and Survival
Depaulis, Antoine [Institut National de la Sante et de la Recherche Medicale, Grenoble, France > > > >]
Vafiadaki, Elizabeth [Foundation for Biomedical Research, Academy of Athens, Athens, Greece > > > >]
Jackers, Pascale [Université de Liège - ULiège > > Center for Analytical Research and Technology (CART) >]
Arvanitis, D. A. [Foundation for Biomedical Research, Academy of Athens, Athens, Greece > > > >]
Kel-Margoulis, Olga [Biobase, GmbH, Wolfenbuettel, Germany > > > >]
Wingender, Edgar [Biobase, GmbH, Wolfenbuettel, Germany > > > >]
Vujasinovic, Todor [HELIOS, Paris, France > > > >]
Greenberg, David [Hebrew University of Jerusalem, Jerusalem, Israel > > > >]
Soreq, Hermona [Hebrew University of Jerusalem, Jerusalem, Israel > > > >]
De Pauw, Edwin mailto [Université de Liège - ULiège > Département de chimie (sciences) > GIGA-R : Laboratoire de spectrométrie de masse (L.S.M.) >]
Dumas Milne Edwards, Jean-Baptiste [HELIOS, Paris, France > > > >]
Sanoudou, Despina [Foundation for Biomedical Research, Academy of Athens, Athens, Greece > > > >]
European Journal of Human Genetics
Nature Publishing Group
Supp 1
Yes (verified by ORBi)
United Kingdom
European Society of Human Genetics Annual Meeting
16/06/2007 au 19/06/2007
Nature Publishing Group npg
[en] cell death ; brain diseases ; molecular interactions ; systems biology ; therapeutic targets ; genomics ; proteomics ; bioinformatics ; dynamic ; microarrays ; 2D-DIGE ; MALDI/TOF-TOF ; regulation ; pathways ; networks
[en] VALAPODYN is a research network funded by the European Commission
(6th Framework Program) which is developing an original systems
biology approach focused on the development of multidisciplinary
functional genomics related to complex biological processes and cellular
networks. The aim is to generate an innovative approach to model
the dynamics of molecular interaction networks (MIN) in relation to cell
death and survival to detect new therapeutic targets to treat human
brain diseases. The project consists of fundamental genomics research
which is integrating statistical data analysis with real biological
data in order to functionally annotate genes and proteins. Specialized
genomics and proteomics databases for MIN modeling are being used
along with leading microarray and proteomics platform systems to investigate
protein-protein interactions and regulation networks. This will
help to identify and validate biological targets in complex intracellular
pathways to cure multifactorial diseases. Dynamic modeling specifically
addresses the systems biology of complex cellular pathways and
transcriptional networks. The novel dynamic models will be validated
by testing the selected drug targets on innovative in vivo and in vitro
models of CNS pathologies.
As opposed to most current biological data analysis methods, VALAPODYN
develops a dynamic and quantitative analysis method for
new therapeutic targets through MIN dynamic models. It will provide
a cutting-edge highly accurate in silico tool for identifying novel and
effective therapeutic targets in a much faster, more efficient and more
economical way than it is possible today. (
Centre Interfacultaire d'Analyse des Résidus en Traces - CART
EU Commission, FP6 (Valapodyn)
‘Validated Predictive Dynamic Model of Complex Intracellular Pathways Related to Cell Death and Survival’
Researchers ; Professionals ; Students

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