[en] BACKGROUND: Positron emission tomography (PET) has been shown useful for the staging of patients with various carcinomas. METHODS: We have applied this technique to 54 cases of colorectal carcinoma and compared it to conventional imaging techniques. RESULTS: PET had moderately higher sensitivity and specificity than conventional techniques to detect individual lesion sites (75% vs 70.8% and 63% vs 21% respectively). It detected the same number of patients with recurrences (35/39) but overestimated disease less frequently (5 cases vs 12). PET favorably influenced therapeutic management in 17 patients, indicating different or additional surgery in 9 while avoiding surgery with curative intent or unnecessary surgery in 8. In 5 cases, erroneous information provided by PET could be corrected by conventional imaging techniques. CONCLUSION: We conclude that PET appears to provide complementary information useful for staging patients with colorectal carcinomas. It can significantly modify patients management. These data should be confirmed by a prospective study.
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Hustinx, Roland ; Université de Liège - ULiège > Département des sciences cliniques > Médecine nucléaire
Paulus, P.
Daenen, Frédéric ; Centre Hospitalier Universitaire de Liège - CHU > Médecine nucléaire
Detroz, Bernard ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Honore, Pierre ; Centre Hospitalier Universitaire de Liège - CHU > Chirurgie abdominale- endocrinienne et de transplantation
Comhair, Nicole ; Centre Hospitalier Universitaire de Liège - CHU > Administration des patients - Expédition
Rigo, Pierre ; Université de Liège - ULiège > Département des sciences de la motricité > Pathologie générale et médecine nucléaire
Language :
French
Title :
Interet clinique de la tomographie a emission de positons dans la detection et le bilan d'extension des recidives des cancers colorectaux
Alternative titles :
[en] Clinical Value of Positron Emission Tomography in the Detection and Staging of Recurrent Colorectal Cancer
Gore RM. Colorectal cancer. Clinical and pathologic features. Radiol Clin North Am 1997;35:403-29.
Mehta S, Johnson RJ, Schofield PF. Staging of colorectal cancer. Clin Radiol 1994;49:515-23.
Safi F, Link KH, Berger HG. Is follow-up of colorectal cancer patients worthwhile ? Dis Colon Rectum 1993;36:636-44.
Moertel CG, Fleming TRR, MacDonald JS, Haller DG, Laurie JA, Tangen C. An evaluation of the carcinoembryonic antigen (CEA) test for monitoring patients with resected colon cancer. JAMA 1993;270:943-7.
Vernava AM, Longo WE, Virgo KS, Coplin MA, Wade TP, Johnson FE. Current follow-up strategies after resection of colon cancer. Results of a survey of members of the American Society of Colon and Rectal Surgeons. Dis Colon Rectum 1994;37:573-83.
Steele G. Standard postoperative monitoring of patients after primary resection of colon and rectum cancer. Cancer 1993;71: 4225-35.
Kievit J, Bruinvels DJ. Detection of recurrence after surgery for colorectal cancer. Eur J Cancer 1995;31A : 1222-5.
Virgo KS, Vernava AM, Longo WE, McKirgan LW, Johnson FE. Cost of patient follow-up after potentially curative colorectal cancer treatment. JAMA 1995;273:1837-41.
Rigo P, Paulus P, Kaschten BJ, Hustinx R, Bury T, Jerusalem G, et al. Oncological applications of positron emission tomography with fluorine-18 fluorodeoxyglucose. Eur J Nucl Med 1996;23: 1641-74.
Wahl RL. Positron emission tomography : application in oncology. In : Murray ICP, EII PJ, eds. Nuclear Medicine, Clinical Diagnosis and Treatment. London : Churchill Livingstone. 1995, 801-20.
Conti PS, Lilien DL, Hawley K, Keppler J, Grafton ST, Bading JR. PET and 18F-FDG in oncology : a clinical update. Nucl Med Biol 1996;23:717-35.
Warburg O, Wind F, Neglers E. On the metabolism of tumors in the body. In : Warburg O, ed. Metabolism of tumors. London : Constable, 1930:254-70.
Schlag P, Lehner B, Strauss LG, Georgi P, Herfarth C. Scar or recurrent rectal cancer. Positron emission tomography is more helpful for diagnosis than immunoscintigraphy. Arch Surg 1989;124:197-200.
Strauss LG, Clorius JH, Schlag P, Lehner B, Kimmig B, Engenhart R, et al. Recurrence of colorectal tumors : PET evaluation. Radiology 1989;170:329-32.
Vitola JV, Delbeke D, Sandler MP, Campbell MG, Powers TA, Wright JK, et al. Positron emission tomography to stage suspected metastatic colorectal carcinoma to the liver. Am J Surg 1996;171: 21-6.
Schiepers C, Penninckx F, De Vadder N, Merckx E, Mortelmans L, Bormans G, et al. Contribution of PET in the diagnosis of recurrent colorectal cancer : comparison with conventional imaging. Eur J Surg Oncol 1995;21:517-22.
Beets G, Penninckx F, Schiepers C, Mortelmans L, Kerremans R, Aerts R, et al. Clinical value of whole-body positron emission tomography with (18F)-fluorodeoxyglucose in recurrent colorectal cancer. Br J Surg 1994;81:1666-70.
Ito K, Kato T, Tadokoro M, Ishiguchi T, Oshima M, Ishigaki T, et al. Recurrent rectal cancer and scar : differentiation with PET and MR imaging. Radiology 1992;182:549-52.
Valk PE, Pounds TR, Tesar RD, Hopkins DM, Haseman MK. Cost-effectiveness of PET imaging in clinical oncology. Nucl Med Biol 1996;23:737-43.
Lai DTM, Fulham M, Stephen MS, Chu KM, Solomon M, Thompson JF, et al. The role of whole-body positron emission tomography with 18F-fluorodeoxyglucose in identifying operable colorectal cancer metastases of the liver. Arch Surg 1996;131: 703-7.
Blend MJ, Abdel-Nabi H. New methods for the staging of colorectal cancer using noninvasive techniques. Semin Surg Oncol 1996;12:253-63.
Delbeke D, Vitola JV, Sandler MP, Arildsen RC, Powers TA, Wright JK, et al. Staging recurrent metastatic colorectal carcinoma with PET. J Nucl Med 1997;38:1196-201.
Beckers C, Paulus P, Rigo P. Evaluation abdomino-pelvienne des cancers ovariens : comparaison de la lomographie à émission de positons au 18-FDG avec la laparotomie exploratrice. Med Nucl Imag Fonct Metab 1996;20:479.
Higashi K, Seki H, Taniguchi M, et al. Bronchioloalveolar carcinoma : false-negative results on FDG-PET (abstract). J Nucl Med 1997;38 (Suppl.) : 79P.
Kinkel K, Tardivon AA, Soyer P, Spatz A, Lasser P, Rougier P, et al. Dynamic contrast-enhanced subtraction versus T2-weighted spin-echo MR imaging in the follow-up of colorectal neoplasm : a prospective study of 41 patients. Radiology 1996;200:453-8.
Karp JS, Muehllehner G, Qu H, Yan XH. Singles transmission in volume-imaging PET with a 137 Cs source. Phys Med Biol 1995;40:929-44.
Cook GJR, Fogelman I, Maisey MN. Normal physiological and benign pathological variants of 18-fluoro-2-deoxyglucose positron-emission tomography scanning : potential for error in interpretation. Semin Nucl Med 1996;26:308-14.