Improved performances of intraocular lenses by poly(ethylene glycol) chemical coatings

[en] Cataract surgery is a routine ophthalmologic intervention resulting in replacement of the opacified natural lens by a polymeric intraocular lens (IOL). A main postoperative complication, as a result of protein adsorption and lens epithelial cell (LEC) adhesion, growth, and proliferation, is the secondary cataract, referred to as posterior capsular opacification (PCO). To avoid PCO formation, a poly(ethylene glycol) (PEG) chemical coating was created on the surface of hydrogel IOLs. Attenuated total reflectance Fourier transform infrared spectroscopy, “captive bubble” and “water droplet” contact angle measurements, and atomic force microscopy analyses proved the covalent grafting of the PEG chains on the IOL surface while keeping unchanged the optical properties of the initial material. A strong decrease of protein adsorption and cell adhesion depending on the molar mass of the grafted PEG (1100, 2000, and 5000 g/mol) was observed by performing the relevant in vitro tests with green fluorescent protein and LECs, respectively. Thus, the study provides a facile method for developing materials with nonfouling properties, particularly IOLs.

Research Center/Unit :

Center for Education and Research on Macromolecules (CERM)

Disciplines :

Chemistry
Materials science & engineering

Author, co-author :

Bozukova, Dimitriya ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Pagnoulle, Christophe; Physiol SA, Liège, Belgium

De Pauw-Gillet, Marie-Claire ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Laboratory of Histology and Cytology

Desbief, Simon; University of Mons-Hainaut (UMH) > Chemistry of New Materials Department

Lazzaroni, Roberto; University of Mons-Hainaut (UMH) > Chemistry of New Materials Department

Ruth, Nadia ; Université de Liège - ULiège > Center for Protein Engineering (CIP)

Jérôme, Robert ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Jérôme, Christine ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)

Language :

English

Title :

Improved performances of intraocular lenses by poly(ethylene glycol) chemical coatings

Publication date :

August 2007

Journal title :

Biomacromolecules

ISSN :

1525-7797

eISSN :

1526-4602

Publisher :

American Chemical Society, Washington, United States - District of Columbia

Volume :

Issue :

Pages :

2379-2387

Peer reviewed :

Peer Reviewed verified by ORBi

Additional URL :

http://pubs.acs.org/doi/pdf/10.1021/bm0701649

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique
The Walloon Region in the frame of the First Europe (SURFOLIO) program
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique

Available on ORBi :

since 03 February 2009

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Bibliography

Lloyd, A. W.; Faragher, R. G. A.; Denyer, S. P. Biomaterials 2001, 22, 769-785.
Saika, S. Prog. Retinal Eye Res. 2004, 23, 283-305.
Hollick, E. J. Optometry 2001, Nov 2, 28-32.
Parsons, C.; Jones, D. S.; Gorman, S. P. Expert Rev. Med. Devices 2005, 2 (2), 161-173.
Liu, C. S. C.; Wormstone, I. M.; Duncan, G.; Marcantonio, J. M.; Webb, S. F.; Davies, P. D. Invest. Ophthalmol. Vis. Sci. 1996, 37, 906-914.
Dumaine, L. Correlation entre les proprietes physico-chimiques de polymeres permettant de moduler la proliferation cellulaire et celles permettant de favoriser le glissement de lentilles intraoculaires. Thesis, Ecole Centrale de Lyon, France, 2004; pp 79-85.
Linnola, R. J.; Werner, L.; Pandey, S. K.; Escobar-Gomez, M.; Znoiko, S. L.; Apple, D. J. J. Cataract Refractive Surg. 2000, 26, 1792-1806.
Linnola, R.; Salonen, J. L; Happonen, R. P. J. Cataract Refractive Surg. 1999, 25, 1480-1485.
Neuhann, I. M.; Werner, L.; Izak, A. M.; Pandey, S. K.; Kleinmann, G.; Mamalis, N.; Neuhann, T. F.; Apple, D. J. Ophthalmology 2004, 111, 2094-2101.
Kooten, T. G.; Koopmans, S.; Terwee, T.; Norrby, S.; Hooymans, J. M. M.; Busscher, H. J. Biomaterials 2006, 27, 5554-5560.
Nagamoto, T.; Fujiwara, T. J. Cataract Refractive Surg. 2003, 29, 1605-1612.
Linnola, R. J.; Sund, M.; Ylönen, R.; Pihlajaniemi, T. J. Cataract Refractive Surg. 2003, 29, 146-152.
Versura, P.; Torreggiani, A.; Cellini, M.; Caramazza, R. J. Cataract Refractive Surg. 1999, 25, 527-533.
Nishi, O.; Nishi, K.; Wickström, K. J. Cataract Refractive Surg. 2000, 26, 1543-1549.
Groot, J. H.; Van Beijma, F. J.; Haitjema, H. J.; Dillingham, K. A.; Hodd, K. A.; Koopmans, S. A.; Norrby, S. Biomacromolecules 2001, 2, 628-634.
Yuan, Z.; Sun, H.; Yuan, J. Graefe's Arch. Clin. Exp. Ophthalmol. 2004, 242 (12), 1008-1013.
Larsson, R.; Selén, G.; Björklund, H.; Fagerholm, P. Biomaterials 1989, 10, 511-516.
Werner, L.; Legeais, J.-M.; Nagel, M.-D.; Renard, G. J. Biomed. Mater. Res. 1999, 46 (3), 347-354.
Hettlich, H. J.; Otterbach, F.; Mittermayer, Ch.; Kaufmann, R.; Klee, D. Biomaterials 1991, 12, 521-524.
Yammine, P.; Pavon-Djavid, G.; Helary, G.; Migonney, V. Biomacromolecules 2005, 6, 2630-2637.
Hélary, G.; Yammine, P.; Migoney, V. J. Appl. Biomater. Biomech. 2004, 2, 183-189.
Lee, J. H.; Oh, S. H. J. Biomed. Mater. Res. 2002, 60 (1), 44-52.
Pasche, S.; De Paul, S. M.; Vörös, J.; Spencer, N. D.; Textor, M. Langmuir 2003, 19 (22), 9216-9225.
Lan, S.; Veiseh, M.; Zhang, M. Biosens. Bioelectron. 2005, 20, 1697-1708.
Lee, J. H.; Lee, H. B.; Andrade, J. D. Prog. Polym. Sci. 1995, 20, 1043-1079.
Vermette, P.; Meagher, L. Colloids Surf., B: Biointerfaces 2003, 28, 153-198.
Nath, N.; Hyun, J.; Ma, H.; Chilkoti, A. Surf. Sci. 2004, 570, 98-110.
Sofia, S. J.; Premnath, V.; Merrill, E. W. Macromolecules 1998, 31, 5059-5070.
Archambault, J. G.; Brash, J. L. Colloids Surf., B: Biointerfaces 2004, 3, 111-120.
Yang, Z.; Galloway, J. A.; Yu, H. Langmuir 1999, 15, 8405 -8411.
Wazawa, T.; Ishizuka-Katsura, Y.; Nishikawa, S.; Iwane, A. H.; Aoyama, S. Anal. Chem. 2006, 78 (8), 2549-2556.
Gong, X.; Dai, L.; Griesser, H. J.; Mau, A. W. H. J. Polym. Sci., Part B: Polym. Phys. 2000, 38, 2323-2332.
Thom, V.; Jankova, K.; Ulbricht, M.; Kops, J.; Jonsson, G. Macromol. Chem. Phys. 1998, 199, 2723-2729.
Silva, S. S.; Menezes, S. M. C.; Garcia, R. B. Eur. Polym. J. 2003, 39, 1515-1519.
Racois, A.; Walsh, D. J. Eur. Polym. J. 1981, 17, 1057-1059.
Lorenz, O.; Decker, H.; Rose, G. Angew. Makromol. Chem. 1984, 122, 83-99.
Bialas, N.; Hocker H. Macromol. Chem. 1990, 191, 1843-1852.
Otsuka, H.; Nagasaki, Y.; Katatoka, K. Biomacromolecules 2000, 1, 39-48.
Groll, J.; Ademovic, Z.; Ameringer, T.; Klee, D.; Moeller, M. Biomacromolecules 2005, 6 (2), 956-962.
Yamakawa, N.; Tanaka, T.; Shigeta, M.; Hamano, M.; Usui, M. J. Cataract Refractive Surg. 2003, 29, 367-370.
Khalid, M. U.S. Patent No. 7083645, 2000.
Klein, L. C.; Beaudry, C. L. Sol-Gel Optics IV; International Society for Optical Engineering: Bellingham, WA, 1997; Vol. 3136, pp 20-24.
Abbott, N. L.; Blankschtein, D.; Halton, T. A. Macromolecules 1991, 24, 4334-4348.
Abbott, N. L.; Blankschtein, D.; Halton, T. A. Macromolecules 1992, 25, 3917-3931.
Abbott, N. L.; Blankschtein, D.; Halton, T. A. Macromolecules 1992, 25, 3932-3941.
Abbott, N. L.; Blankschtein, D.; Halton, T. A. Macromolecules 1992, 25, 5192-5200.
Jeon, S. I.; Lee, J. H.; Andrare, J. D.; De Gennes, P. G. J. Colloid Interface Sci. 1991, 142 (1), 149-158.
Jeon, S. L; Andrare, J. D. J. Colloid Interface Sci. 1991, 142 (1), 159-166.
Gref, R.; Lück, M.; Quellec, P.; Marchand, M.; Dellacherie, E.; Harnisch, S.; Blunk, T.; Müller, R. H. Colloids Surf., B: Biointerfaces 2000, 18, 301-313,
Freshney, R. I. Culture of animal cells; Wiley-Liss, Inc.: New York, 1994.

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