[en] The ganglionic cell type in which varicellazoster virus (VZV) is latent in humans was analyzed by using antibodies raised against in vitro-expressed VZV open reading frame 63 protein, VZV open reading frame 63 protein was detected exclusively in the cytoplasm of neurons of latently infected human trigeminal and thoracic ganglia. This is, to our knowledge, the first identification of a herpesvirus protein expressed during latency in the human nervous system.
Disciplines :
Immunology & infectious disease
Author, co-author :
Mahalingam, Ravy; University of Denver Medical School, Denver, CO, USA
Wellish, Mary; University of Denver Medical School, Denver, CO, USA
Cohrs, Randall; University of Denver Medical School, Denver, CO, USA
Debrus, Serge; Université de Liège - ULiège > Département des Sciences de la Vie > Virologie fondamentale & Immunologie
Piette, Jacques ; Université de Liège - ULiège > Département des sciences de la vie > Virologie fondamentale & Immunologie
Rentier, Bernard ; Université de Liège - ULiège > Département des Sciences de la Vie > Virologie fondamentale et Immunologie
Gilden, Donald H.; University of Denver Medical School, Denver, CO, USA
Language :
English
Title :
Expression of protein encoded by varicella-zoster virus open reading frame 63 in latently infected human ganglionic neurons
Publication date :
1996
Journal title :
Proceedings of the National Academy of Sciences of the United States of America
