Article (Scientific journals)
Proteases, extracellular matrix and cancer: a workshop of the path B study section
Declerck, Y. A.; Mercurio, A. M.; Stack, M. S. et al.
2004In American Journal of Pathology, 164 (4), p. 1131-39
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Abstract :
[en] The role of the extracellular matrix (ECM) in the tumor microenvironment is not limited to being a barrier against tumor invasion. The ECM is a reservoir of cell binding proteins and growth factors that affect tumor cell behavior. It is also substantially modified by proteases produced by tumor cells or stroma cells. As a result of the activity of these proteases, cell-cell and cell-ECM interactions are altered, new biologically active ECM molecules are generated, and the bioavailability and activity of many growth factors, growth factor receptors, and cytokines are modified. ECM-degrading proteases also play a critical role in angiogenesis, where they can act as positive as well as negative regulators of endothelial cell proliferation and vascular morphogenesis. This review article summarizes some of the most relevant findings made over the recent years that were discussed at a workshop organized by the Path B Study Section of the National Institutes of Health in October 2002.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Declerck, Y. A.
Mercurio, A. M.
Stack, M. S.
Chapman, H. A.
Zutter, M. M.
Muschel, R. J.
Raz, A.
Matrisian, L. M.
Sloane, B. F.
Noël, Agnès  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biologie cellulaire et moléculaire appliquée à l'homme
Hendrix, M. J.
Coussens, L.
Padarathsingh, M.
More authors (3 more) Less
Language :
English
Title :
Proteases, extracellular matrix and cancer: a workshop of the path B study section
Publication date :
2004
Journal title :
American Journal of Pathology
ISSN :
0002-9440
eISSN :
1525-2191
Publisher :
American Society for Investigative Pathology, Bethesda, United States - Maryland
Volume :
164
Issue :
4
Pages :
1131-39
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 12 January 2010

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