Reference : Synthesis and tissue distribution of four Se-labeled tertiary amines, potential brain...
Scientific journals : Article
Human health sciences : Radiology, nuclear medicine & imaging
Synthesis and tissue distribution of four Se-labeled tertiary amines, potential brain pH imaging agents.
Plenevaux, Alain mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Cantineau, Robert [> > > >]
Brihaye, Claude [> > > >]
Lemaire, Christian mailto [Université de Liège - ULiège > > Centre de recherches du cyclotron >]
Christiaens, Léon [> >]
Guillaume, Marcel [> >]
International Journal of Radiation Applications and Instrumentation. Part B : Nuclear Medicine and Biology
Pergamon Press
Yes (verified by ORBi)
United Kingdom
[en] Amines/chemical synthesis/pharmacokinetics ; Animals ; Brain Chemistry ; Female ; Hydrogen-Ion Concentration ; Rats ; Selenium/pharmacokinetics ; Selenium Radioisotopes/diagnostic use ; Tissue Distribution
[en] Four new tertiary amines: bis(3-N,N-dimethyl aminopropyl)selenide (PROMOSE), bis(3-N-(morpholino)propyl)selenide, N-methyl-selenomorpholine and N-phenyl-selenomorpholine structurally related to MOSE proposed by Kung and Blau, have been labeled through a radiochemical procedure suitable for both 75Se and 73Se. The radiochemical yields of the carrier added synthesis ranged between 64 and 85% for the four 75Se labelings and was 64% EOB time corrected for [73Se]PROMOSE. The chemical and radiochemical purities were higher than 99% after chromatographic purifications. The n-octanol/phosphate buffer partition coefficients (P) were measured at various pH (6.5-8) for each compound and the tissue distributions of PROMOSE in rats were also carried out. The experimental results showed a good correlation between the P = f(pH) function and the in vivo behaviour of the considered compound. PROMOSE was selected for further investigations as a brain pH indicator.
Centre de Recherches du Cyclotron - CRC
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals ; Students

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