[en] Porous poly(D,L-lactide) PDLLA foams containing 0, 5 and 20 wt% of TiO2 nanoparticles were fabricated and characterised. The addition of Bioglassg particles was also studied in a composite containing 5 wt% of Bioglass(R) particles and 20 wt% of TiO2 nanoparticles. The microstructure of the four different foam types was characterised using scanning electron microscopy (SEM) and their mechanical properties assessed by quasi-static compression testing. The in vitro behaviour of the foams was studied in simulated body fluid (SBF) at three different time points: 3, 21 and 28 days. The degradation of the samples was characterised quantitatively by measuring the water absorption and weight loss as a function of immersion time in SBE The bioactivity of the foams was characterised by observing hydroxyapatite (HA) formation after 21 days of immersion in SBF using SEM and confirmed with X-ray diffraction (XRD) analysis. It was found that the amount of HA was dependent on the distribution of TiO2 nanoparticles and on the presence of Bioglassg in the foam samples. (c) 2006 Springer Science + Business Media, Inc.
Research center :
Center for Education and Research on Macromolecules (CERM)
Disciplines :
Chemistry Materials science & engineering
Author, co-author :
Boccaccini, Aldo R.; Imperial College London, London, UK > Department of Materials and Centre for Tissue Engineering and Regenerative Medicine
Blaker, Jonny J.; Imperial College London, London, UK > Department of Materials and Centre for Tissue Engineering and Regenerative Medicine
Maquet, Véronique; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Chung, Wendy; Imperial College London, London, UK > Department of Materials and Centre for Tissue Engineering and Regenerative Medicine
Jérôme, Robert ; Université de Liège - ULiège > Department of Chemistry > Center for Education and Research on Macromolecules (CERM)
Nazhat, Showan N.; Eastman Dental Institute, University College, London, UK > Division of Biomaterials and Tissue Engineering, Eastman Dental Institute
Language :
English
Title :
Poly(D,L-lactide) (PDLLA) foams with TiO2 nanoparticles and PDLLA/TiO2-Bioglass (R) foam composites for tissue engineering scaffolds
BELSPO - SPP Politique scientifique - Service Public Fédéral de Programmation Politique scientifique EPSRC - Engineering and Physical Sciences Research Council [GB]
Commentary :
The original publication is available at http://www.springerlink.com/content/3x579751q18193t2/fulltext.pdf. The authors acknowledge Journal of Materials Science (Springer) for allowing them to archive this paper.
