Article (Scientific journals)
Chronic verrucous varicella zoster virus skin lesions: clinical, histological, molecular and therapeutic aspects
Nikkels, Arjen; Snoeck, Robert; Rentier, Bernard et al.
1999In Clinical and Experimental Dermatology, 24 (5), p. 346-353
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Abstract :
[en] The outbreak of HIV infection introduced a new phenomenon in varicella zoster virus (VZV) pathology, namely the long-standing wart-like skin lesions that are frequently associated with resistance to thymidine kinase (TK)-dependent antiviral agents. This paper reviews the clinical, histological, and molecular aspects and the therapeutic management of these verrucous lesions. The majority of lesions are characterized by chronically evolving, unique or multiple wart-like cutaneous lesions. The main histopathological features include hyperkeratosis, verruciform acanthosis and VZV-induced cytopathic changes with scant or absent cytolysis of infected keratinocytes. The mechanism that establishes the chronic nature of the lesions appears to be associated with a particular pattern of VZV gene expression exhibiting reduced or nondetectable gE and gB synthesis. Drug resistance to TK-dependent antiviral agents is a result of nonfunctional or deficient viral TK. This necessitates alternative therapeutic management using antiviral agents that target the viral DNA polymerase.
Disciplines :
Immunology & infectious disease
Dermatology
Author, co-author :
Nikkels, Arjen ;  Université de Liège - ULiège > Dermatologie
Snoeck, Robert
Rentier, Bernard  ;  Université de Liège - ULiège > Services administratifs généraux > Recteur - GIGA-R : Virologie - Immunologie
Pierard, Gérald ;  Université de Liège - ULiège > Dermatopathologie
Language :
English
Title :
Chronic verrucous varicella zoster virus skin lesions: clinical, histological, molecular and therapeutic aspects
Publication date :
September 1999
Journal title :
Clinical and Experimental Dermatology
ISSN :
0307-6938
eISSN :
1365-2230
Publisher :
Blackwell
Volume :
24
Issue :
5
Pages :
346-353
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
The definitive version is available at http://www.blackwell-synergy.com/doi/pdf/10.1046/j.1365-2230.1999.00498.x
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