Article (Scientific journals)
Inhibition des recepteurs CB1 et metabolisme du glucose: rimonabant dans le diabete de type 2.
Scheen, André; Paquot, Nicolas; Van Gaal, Luc F
2008In Revue Médicale Suisse, 4 (168), p. 1812-7
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Keywords :
Blood Glucose/metabolism; Diabetes Mellitus, Type 2/drug therapy/metabolism; Humans; Hypoglycemic Agents/therapeutic use; Piperidines/therapeutic use; Pyrazoles/therapeutic use; Receptor, Cannabinoid, CB1/antagonists & inhibitors/metabolism
Abstract :
[en] Endocannabinoid system is overactivated in individuals with abdominal obesity. CBI receptors, first individualized in the brain, are also expressed in the adipocyte, the skeletal muscle, the liver, the gut, and the pancreas. Their blockade improves glucose tolerance and lipid profile, thanks increased insulin sensitivity and adiponectin levels. Rimonabant, a selective antagonist of CBI receptors, improves glucose control in patients with type 2 diabetes, treated with diet alone, metformin, sulfonylurea or insulin, while it also reduces body weight and other risk factors. Ongoing studies aim at further demonstrating the potential of rimonabant in the management of type 2 diabetes, in the prevention of type 2 diabetes and in the protection against cardiovascular complications in (diabetic) patients with abdominal obesity.
Disciplines :
Endocrinology, metabolism & nutrition
Author, co-author :
Scheen, André  ;  Université de Liège - ULiège > Département des sciences cliniques > Diabétologie, nutrition et maladie métaboliques - Médecine interne générale
Paquot, Nicolas ;  Centre Hospitalier Universitaire de Liège - CHU > Diabétologie,nutrition, maladies métaboliques
Van Gaal, Luc F
Language :
French
Title :
Inhibition des recepteurs CB1 et metabolisme du glucose: rimonabant dans le diabete de type 2.
Alternative titles :
[fr] CB1 receptor inhibition and glucose metabolism: role of rimonabant in type 2 diabetes
Publication date :
2008
Journal title :
Revue Médicale Suisse
ISSN :
1660-9379
Publisher :
Medecine et Hygiène, Switzerland
Volume :
4
Issue :
168
Pages :
1812-7
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
Tous nos remerciements à Médecine & Hygienne
Available on ORBi :
since 30 January 2009

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