Article (Scientific journals)
F-18-FDG PET in children with lymphomas
Depas, Gisèle; De Barsy, Caroline; Jerusalem, Guy et al.
2005In European Journal of Nuclear Medicine and Molecular Imaging, 32 (1), p. 31-38
Peer Reviewed verified by ORBi
 

Files


Full Text
G. Depas Lymphomas EJNM 2005.pdf
Publisher postprint (269.26 kB)
Request a copy

All documents in ORBi are protected by a user license.

Send to



Details



Keywords :
F-18-fluorodeoxyglucose; positron emission tomography; child; lymphoma; oncology
Abstract :
[en] Purpose: The aim of this study was to retrospectively evaluate the performance of positron emission tomography (PET) with F-18-fluorodeoxyglucose (F-18-FDG) in children with lymphomas, at various stages of their disease. Methods: Twenty-eight children (mean age 12.5 years, 14 girls, 14 boys) with Hodgkin's disease (HD, n=17) or non-Hodgkin's lymphoma (NHL, n= 11) were evaluated. Patients were investigated at initial staging (n=19), early in the course of treatment (n=19), at the end of treatment (n=16) and during long-term follow-up (n=19). A total of 113 whole-body PET studies were performed on dedicated scanners. PET results were compared with the results of conventional methods (CMs) such as physical examination, laboratory studies, chest X-rays, computed tomography, magnetic resonance imaging, ultrasonography and bone scan when available. Results: At initial evaluation (group 1), PET changed the disease stage and treatment in 10.5% of the cases. In early evaluation of the response to treatment (group 2), PET failed to predict two relapses and one incomplete response to treatment. In this group, however, PET did not show any false positive results. There were only 4/75 false positive results for PET among patients studied at the end of treatment (group 3, specificity 94%) or during the systematic follow-up (group 4, specificity 95%), as compared with 27/75 for CMs (specificity 54% and 66%, respectively). Conclusion: F-18-FDG-PET is a useful tool for evaluating children with lymphomas. Large prospective studies are needed to appreciate its real impact on patient management.
Disciplines :
Radiology, nuclear medicine & imaging
Author, co-author :
Depas, Gisèle ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine nucléaire
De Barsy, Caroline
Jerusalem, Guy  ;  Centre Hospitalier Universitaire de Liège - CHU > Oncologie médicale
Hoyoux, Claire ;  Université de Liège - ULiège > Département des sciences cliniques
DRESSE, Marie-Françoise 
Fassotte, Marie-France ;  Centre Hospitalier Universitaire de Liège - CHU > Hématologie clinique
Paquet, Nancy;  Hôtel de Dieu (Lévis, Québec) > Division of Nuclear Medicine
Willems, Jacqueline ;  Centre Hospitalier Universitaire de Liège - CHU > Médecine nucléaire
Rigo, Pierre ;  Université de Liège - ULiège > Département des sciences de la motricité > Pathologie générale et médecine nucléaire
Hustinx, Roland  ;  Université de Liège - ULiège > Département des sciences cliniques > Médecine nucléaire
Language :
English
Title :
F-18-FDG PET in children with lymphomas
Publication date :
January 2005
Journal title :
European Journal of Nuclear Medicine and Molecular Imaging
ISSN :
1619-7070
eISSN :
1619-7089
Publisher :
Springer, New York, United States - New York
Volume :
32
Issue :
1
Pages :
31-38
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 29 January 2009

Statistics


Number of views
99 (6 by ULiège)
Number of downloads
4 (3 by ULiège)

Scopus citations®
 
104
Scopus citations®
without self-citations
100
OpenCitations
 
103

Bibliography


Similar publications



Contact ORBi