Article (Scientific journals)
Fast Routine Production of L-[11C-methyl]methionine with Al2O3KF
Schmitz, Frédéric; Plenevaux, Alain; Del-Fiore, Guy et al.
1995In Applied Radiation and Isotopes, 46 (9), p. 893-897
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Keywords :
Carbon-11; methionine; PET; Al2O3/KF
Abstract :
[en] No-carrier-added (nca) L-[11C-methyl]methionine was prepared via the very fast S-alkylation of L-homocysteine adsorbed on AI203/KF with [11C]iodomethane at room temperature in ethanol. The alkylation was realized with a radiochemical yield of 94 +/- 4% EOB (n = 20). More than 90% (n = 20) of the precursor L-homocysteine remained adsorbed on the solid support and was eliminated by a simple filtration. After reaction, neither racemization nor by-product were detected. The purification process was thus limited to a C18 Sep-Pak followed by an alumina Sep-Pak. The radiochemical purity measured on the final solution was shown to be > 99%. The only chemical contaminant was L-homocysteine (+ 10 µg). With this new technique, L-[11C-methyl]methionine was ready for injection within 10 min from [11C]CO2 with a specific activity ranging around 37 + 5.6 GBq (1 +/- 0.15 Ci)//tmol EOB. Through this procedure L-[11C-methyl]methionine can be prepared without preparative HPLC purification, This is an important simplification for the fast routine production of one of the most widely used radiopharmaceutical compounds for PET.
Research Center/Unit :
GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Disciplines :
Physical, chemical, mathematical & earth Sciences: Multidisciplinary, general & others
Author, co-author :
Schmitz, Frédéric
Plenevaux, Alain  ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Del-Fiore, Guy
Lemaire, Christian ;  Université de Liège - ULiège > Centre de recherches du cyclotron
Comar, Dominique
Luxen, André ;  Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron
Language :
English
Title :
Fast Routine Production of L-[11C-methyl]methionine with Al2O3KF
Publication date :
1995
Journal title :
Applied Radiation and Isotopes
ISSN :
0969-8043
Publisher :
Pergamon-Elsevier Science, Oxford, United Kingdom
Volume :
46
Issue :
9
Pages :
893-897
Peer reviewed :
Peer Reviewed verified by ORBi
Funders :
F.R.S.-FNRS - Fonds de la Recherche Scientifique
Available on ORBi :
since 29 January 2009

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