Development and evaluation of an automated atlas-based image analysis method for microPET studies of the rat brain.

Animals; Atlases as Topic; Automation; Brain/anatomy & histology/radionuclide imaging; Brain Mapping/methods; Cerebellum/physiology/radionuclide imaging; Cerebral Cortex/physiology/radionuclide imaging; Dopamine/physiology; Hippocampus/physiology/radionuclide imaging; Image Interpretation, Computer-Assisted/methods; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Neostriatum/physiology/radionuclide imaging; Rats; Rats, Sprague-Dawley; Serotonin/physiology; Thalamus/physiology/radionuclide imaging; Tomography, Emission-Computed/standards; Tomography, Emission-Computed, Single-Photon

Abstract :

[en] An automated method for placement of 3D rat brain atlas-derived volumes of interest (VOIs) onto PET studies has been designed and evaluated. VOIs representing major structures of the rat brain were defined on a set of digitized cryosectioned images of the rat brain. For VOI placement, each PET study was registered with a synthetic PET target constructed from the VOI template. Registration was accomplished with an automated algorithm that maximized the mutual information content of the image volumes. The accuracy and precision of this method for VOI placement was determined using datasets from PET studies of the striatal dopamine and hippocampal serotonin systems. Each evaluated PET study could be registered to at least one synthetic PET target without obvious failure. Registration was critically dependent upon the initial position of the PET study relative to the synthetic PET target, but not dependent on the amount of synthetic PET target smoothing. An evaluation algorithm showed that resultant radioactivity concentration measurements of selected brain structures had errors=2% due to misalignment with the corresponding VOI. Further, radioligand binding values calculated from these measurements were found to be more precise than those calculated from measurements obtained with manually drawn regions of interest (ROIs). Overall, evaluation results demonstrated that this atlas-derived VOI method can be used to obtain unbiased measurements of radioactivity concentration from PET studies. Its automated features, and applicability to different radioligands and brain regions, will facilitate quantitative rat brain PET assessment procedures.

Research Center/Unit :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Molecular and medical pharmacology UCLA

Disciplines :

Radiology, nuclear medicine & imaging

Author, co-author :

Rubins, Daniel J.

Melega, William P.

Lacan, Goran

Way, Baldwin

Plenevaux, Alain ; Université de Liège - ULiège > Centre de recherches du cyclotron

Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron

Cherry, Simon R.

Language :

English

Title :

Development and evaluation of an automated atlas-based image analysis method for microPET studies of the rat brain.

Publication date :

2003

Journal title :

NeuroImage

ISSN :

1053-8119

eISSN :

1095-9572

Publisher :

Academic Press, Orlando, United States - Florida

Volume :

Issue :

Pages :

2100-18

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique [BE]
UCLA - University of California, Los Angeles [US-CA] [US-CA]

Available on ORBi :

since 29 January 2009

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104

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100

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108

Bibliography

Ait Amara D., Segu L., Buhot M.C. Region-specific decrease in 5-HT1A and 5-HT1B binding sites after intra-hippocampal ibotenic acid injections in the rat. Neurosci. Lett. 310:2001;25-28.
Ardekani B.A., Braun M., Hutton B.F., Kanno I., Iida H. A fully automatic multimodality image registration algorithm. J. Comput. Assist. Tomogr. 19:1995;615-623.
Bauer B., Wagner R. Production of [11C]raclopride with high specific activity for clinical use. J. Labelled Comput. Radiopharm. 35:1994;464-465.
Bohm C., Greitz T., Blomqvist G., Farde L., Forsgren P.O., Kingsley D., Sjogren I., Wiesel F., Wik G. Applications of a computerized adjustable brain atlas in positron emission tomography. Acta. Radiol. Suppl. 369:1986;449-452.
Brownell A.L., Elmaleh D.R., Meltzer P.C., Shoup T.M., Brownell G.L., Fischman A.J., Madras B.K. Cocaine congeners as PET imaging probes for dopamine terminals. J. Nucl. Med. 37:1996;1186-1192.
Chatziioannou A., Qi J., Moore A., Annala A., Nguyen K., Leahy R., Cherry S.R. Comparison of 3-D maximum a posteriori and filtered backprojection algorithms for high-resolution animal imaging with microPET. IEEE Trans. Med. Imaging. 19:2000;507-512.
Cherry S.R., Shao Y., Silverman R.W., Meadors K., Siegel S., Chatziioannou A., Young J.W., Jones W., Moyers J.C., Newport D., Boutefnouchet A., Farquhar T.H., Andreaco M., Paulus M.J., Binkley D.M., Nutt R., Phelps M.E. MicroPET a high resolution PET scanner for imaging small animals . IEEE Trans. Nucl. Sci. 44:1997;1161-1166.
Cicchetti F., Brownell A.L., Williams K., Chen Y.I., Livni E., Isacson O. Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging. Eur. J. Neurosci. 15:2002;991-998.
Cohen A.D., Tillerson J.L., Smith A.D., Schallert T., Zigmond M.J. Neuroprotective effects of prior limb use in 6-hydroxydopamine-treated rats possible role of GDNF . J. Neurochem. 85:2003;299-305.
Farde L., Hall H., Ehrin E., Sedvall G. Quantitative analysis of D2 dopamine receptor binding in the living human brain by PET. Science. 231:1986;258-261.
Hayakawa N., Uemura K., Ishiwata K., Shimada Y., Ogi N., Nagaoka T., Toyama H., Oda K., Tanaka A., Endo K., Senda M. A PET-MRI registration technique for PET studies of the rat brain. Nucl. Med. Biol. 27:2000;121-125.
Hoffman E.J., Huang S.C., Phelps M.E. Quantitation in positron emission computed tomography 1. Effect of object size . J. Comput. Assist. Tomogr. 3:1979;299-308.
Maes F., Collignon A., Vandermeulen D., Marchal G., Suetens P. Multimodality image registration by maximization of mutual information. IEEE Trans. Med. Imaging. 16:1997;187-198.
Melega W.P., Lacan G., Desalles A.A., Phelps M.E. Long-term methamphetamine-induced decreases of [(11)C]WIN 35,428 binding in striatum are reduced by GDNF PET studies in the vervet monkey . Synapse. 35:2000;243-249.
Minoshima S., Koeppe R.A., Frey K.A., Ishihara M., Kuhl D.E. Stereotactic PET atlas of the human brain aid for visual interpretation of functional brain images . J. Nucl. Med. 35:1994;949-954.
Nikolaus S., Larisch R., Beu M., Forutan F., Vosberg H., Muller-Gartner H.W. Bilateral increase in striatal dopamine D(2) receptor density in the 6-hydroxydopamine-lesioned rat a serial in vivo investigation with small animal PET . Eur. J. Nucl. Med. Mol. Imaging. 30:2003;390-395.
Paxinos G., Watson C. The Rat Brain in Stereotaxic Coordinates. second ed :1986;Academic Press, Sydney.
Paxinos G., Watson C., Pennisi M., Topple A. Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight. J. Neurosci. Methods. 13:1985;139-143.
Pelizzari C.A., Chen G.T., Spelbring D.R., Weichselbaum R.R., Chen C.T. Accurate three-dimensional registration of CT, PET, and/or MR images of the brain. J. Comput. Assist. Tomogr. 13:1989;20-26.
Plenevaux A., Lemaire C., Aerts J., Lacan G., Rubins D., Melega W.P., Brihaye C., Degueldre C., Fuchs S., Salmon E., Maquet P., Laureys S., Damhaut P., Weissmann D., Le Bars D., Pujol J.F., Luxen A. [(18)F]p-MPPF a radiolabeled antagonist for the study of 5-HT(1A) receptors with PET . Nucl. Med. Biol. 27:2000;467-471.
Press W.H., Teukolsky S.A., Vettering W.T., Flannery B.P. Numerical Recipes in C The Art of Scientific Computing . second ed :1997;Cambridge University Press, Cambridge.
Qi J., Leahy R.M., Cherry S.R., Chatziioannou A., Farquhar T.H. High-resolution 3D bayesian image reconstruction using the microPET small-animal scanner. Phys. Med. Biol. 43:1998;1001-1013.
Rousset O.G., Ma Y., Evans A.C. Correction for partial volume effects in PET principle and validation . J. Nucl. Med. 39:1998;904-911.
Rubins D.J., Meadors A.K., Yee S., Melega W.P., Cherry S.R. Evaluation of a stereotactic frame for repositioning of the rat brain in serial PET imaging studies. J. Neurosci. Methods. 107:2001;63-70.
Schaltenbrand G., Wahren W. Atlas for Stereotaxy of the Human Brain. 1977;Georg Thieme Verlag, Stuttgart.
Siegel S., Dahlbom M. Implementation and evaluation of a calculated attenuation correction for PET. IEEE Trans. Nucl. Sci. 39:1992;1117-1121.
Slifstein M., Mawlawi O., Lauruelle M. Partial volume effect correction Methodological considerations . Paulson O. Physiological Imaging of the Brain with PET. 2000;65-71 Academic Press, San Diego.
Studholme C., Hill D.L., Hawkes D.J. Automated three-dimensional registration of magnetic resonance and positron emission tomography brain images by multiresolution optimization of voxel similarity measures. Med. Phys. 24:1997;25-35.
Swanson L.W. Brain Maps Structure of the Rat Brain . 1992;Elsevier, Amsterdam.
Tai C., Chatziioannou A., Siegel S., Young J., Newport D., Goble R.N., Nutt R.E., Cherry S.R. Performance evaluation of the microPET P4 a PET system dedicated to animal imaging . Phys. Med. Biol. 46:2001;1845-1862.
Talairach J., Tournoux P. Co-Planar Stereotaxic Atlas of the Human Brain 3-Dimensional Proportional System: An Approach to Cerebral Imaging by Jean Talairach and Pierre Tournoux; Translated by Mark Rayport . 1988;Thieme Medical Publishers, New York.
Thompson P.M., Woods R.P., Mega M.S., Toga A.W. Mathematical/ computational challenges in creating deformable and probabilistic atlases of the human brain. Hum. Brain. Mapp. 9:2000;81-92.
Toga A.W., Santori E.M., Hazani R., Ambach K. A 3D digital map of rat brain. Brain. Res. Bull. 38:1995;77-85.
Wells W.M. 3rd, Viola P., Atsumi H., Nakajima S., Kikinis R. Multi-modal volume registration by maximization of mutual information. Med. Image Anal. 1:1996;35-51.
Wilson A.A., DaSilva J.N., Houle S. In vivo evaluation of [11C]- and [18F]-labelled cocaine analogues as potential dopamine transporter ligands for positron emission tomography. Nucl. Med. Biol. 23:1996;141-146.
Woods R.P., Cherry S.R., Mazziotta J.C. Rapid automated algorithm for aligning and reslicing PET images. J. Comput. Assist. Tomogr. 16:1992;620-633.
Woods R.P., Grafton S.T., Holmes C.J., Cherry S.R., Mazziotta J.C. Automated image registration I. General methods and intrasubject, intramodality validation . J. Comput. Assist. Tomogr. 22:1998;139-152.
Woods R.P., Grafton S.T., Watson J.D., Sicotte N.L., Mazziotta J.C. Automated image registration II. Intersubject validation of linear and nonlinear models . J. Comput. Assist. Tomogr. 22:1998;153-165.
Woods R.P., Mazziotta J.C., Cherry S.R. MRI-PET registration with automated algorithm. J. Comput. Assist. Tomogr. 17:1993;536-546.