Development and evaluation of an automated atlas-based image analysis method for microPET studies of the rat brain.

Animals; Atlases as Topic; Automation; Brain/anatomy & histology/radionuclide imaging; Brain Mapping/methods; Cerebellum/physiology/radionuclide imaging; Cerebral Cortex/physiology/radionuclide imaging; Dopamine/physiology; Hippocampus/physiology/radionuclide imaging; Image Interpretation, Computer-Assisted/methods; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Neostriatum/physiology/radionuclide imaging; Rats; Rats, Sprague-Dawley; Serotonin/physiology; Thalamus/physiology/radionuclide imaging; Tomography, Emission-Computed/standards; Tomography, Emission-Computed, Single-Photon

Abstract :

[en] An automated method for placement of 3D rat brain atlas-derived volumes of interest (VOIs) onto PET studies has been designed and evaluated. VOIs representing major structures of the rat brain were defined on a set of digitized cryosectioned images of the rat brain. For VOI placement, each PET study was registered with a synthetic PET target constructed from the VOI template. Registration was accomplished with an automated algorithm that maximized the mutual information content of the image volumes. The accuracy and precision of this method for VOI placement was determined using datasets from PET studies of the striatal dopamine and hippocampal serotonin systems. Each evaluated PET study could be registered to at least one synthetic PET target without obvious failure. Registration was critically dependent upon the initial position of the PET study relative to the synthetic PET target, but not dependent on the amount of synthetic PET target smoothing. An evaluation algorithm showed that resultant radioactivity concentration measurements of selected brain structures had errors=2% due to misalignment with the corresponding VOI. Further, radioligand binding values calculated from these measurements were found to be more precise than those calculated from measurements obtained with manually drawn regions of interest (ROIs). Overall, evaluation results demonstrated that this atlas-derived VOI method can be used to obtain unbiased measurements of radioactivity concentration from PET studies. Its automated features, and applicability to different radioligands and brain regions, will facilitate quantitative rat brain PET assessment procedures.

Research Center/Unit :

GIGA CRC (Cyclotron Research Center) In vivo Imaging-Aging & Memory - ULiège
Molecular and medical pharmacology UCLA

Disciplines :

Radiology, nuclear medicine & imaging

Author, co-author :

Rubins, Daniel J.

Melega, William P.

Lacan, Goran

Way, Baldwin

Plenevaux, Alain ; Université de Liège - ULiège > Centre de recherches du cyclotron

Luxen, André ; Université de Liège - ULiège > Département de chimie (sciences) > Chimie organique de synthèse - Centre de recherches du cyclotron

Cherry, Simon R.

Language :

English

Title :

Development and evaluation of an automated atlas-based image analysis method for microPET studies of the rat brain.

Publication date :

2003

Journal title :

NeuroImage

ISSN :

1053-8119

eISSN :

1095-9572

Publisher :

Academic Press, Orlando, United States - Florida

Volume :

Issue :

Pages :

2100-18

Peer reviewed :

Peer Reviewed verified by ORBi

Funders :

F.R.S.-FNRS - Fonds de la Recherche Scientifique
UCLA - University of California, Los Angeles

Available on ORBi :

since 29 January 2009

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Scopus citations^®

104

Scopus citations^®
without self-citations

100

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108

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