The vestibulo-collic reflex is abnormal in migraine

[en] Interictal evoked central nervous system responses are characterized in migraineurs by a deficit of habituation, at both cortical and subcortical levels. The click-evoked vestibulo-collic reflex (VCR) allows the assessment of otolith function and an oligosynaptic pathway linking receptors in the saccular macula to motoneurons of neck muscles. Three blocks of 75 averaged responses to monaural 95-dB normal hearing level 3-Hz clicks were recorded over the contracted ipsilateral sternocleidomastoid muscle in 25 migraineurs between attacks and 20 healthy subjects, without vestibular symptoms. Amplitudes, raw and corrected for baseline electromyography, were significantly smaller in migraine patients. Whereas in healthy volunteers the VCR habituated during stimulus repetition (-4.96% +/- 14.3), potentiation was found in migraineurs (4.34% +/- 15.3; P = 0.04). The combination with a reduced mean amplitude does not favour vestibular hyperexcitability as an explanation for the habituation deficit in migraine, but rather an abnormal processing of repeated stimuli in the reflex circuit.

Disciplines :

Neurosciences & behavior
Neurology

Author, co-author :

Allena, M.

Magis, Delphine ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie Sart Tilman

De Pasqua, Victor ; Centre Hospitalier Universitaire de Liège - CHU > Neurologie CHR

Schoenen, Jean ; Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie

Language :

English

Title :

The vestibulo-collic reflex is abnormal in migraine

Publication date :

October 2007

Journal title :

Cephalalgia

ISSN :

0333-1024

eISSN :

1468-2982

Publisher :

Blackwell Science

Volume :

Issue :

Pages :

1150-1155

Peer reviewed :

Peer Reviewed verified by ORBi

Available on ORBi :

since 28 January 2009

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Bibliography

Schoenen J, Ambrosini A, Sándor PS, Maertens de Noordhout A. Evoked potentials and transcranial magnetic stimulation in migraine: published data and viewpoint on their pathophysiologic significance. Clin Neurophysiol 2003 114 : 955 72.
Ozkul Y, Uckardes A. Median nerve somatosensory evoked potentials in migraine. Eur J Neurol 2002 9 : 227 32.
Katsarava Z, Giffin N, Diener HC, Kaube H. Abnormal habituation of 'nociceptive' blink reflex in migraine - evidence for increased excitability of trigeminal nociception. Cephalalgia 2003 23 : 814 9.
Di Clemente L, Coppola G, Magis D, Fumal A, De Pasqua V, Schoenen J. Nociceptive blink reflex and visual evoked potentials habituation are correlated in migraine. Headache 2005 45 : 1388 93.
Mulleners WM, Chronicle EP, Palmer JE, Koehler PJ, Vredeveld JW. Visual cortex excitability in migraine with and without aura. Headache 2001 41 : 565 72.
Neuhauser HK, Radtke A, von Brevern M, Feldmann M, Lezius F, Ziese T, Lempert T. Migrainous vertigo: prevalence and impact on quality of life. Neurology 2006 67 : 1028 33.
Furman JM, Marcus DA, Balaban CD. Migrainous vertigo: development of a pathogenetic model and structured diagnostic interview. Curr Opin Neurol 2003 16 : 5 13.
Harno H, Hirvonen T, Kaunisto MA, Imagawa M, Ikegami H, Isu N, et al. Subclinical vestibulocerebellar dysfunction in migraine with and without aura. Neurology 2003 61 : 1748 52.
Helm MR. Vestibulo-ocular reflex abnormalities in patients with migraine. Headache 2005 45 : 332 6.
Sándor PS, Mascia A, Seidel L, De Pasqua V, Schoenen J. Subclinical cerebellar impairment in the common types of migraine: a 3-dimensional analysis of reaching movements. Ann Neurol 2001 49 : 668 72.
Colebatch JG, Halmaygi GM, Skuse NF. Myogenic potentials generated by a click-evoked vestibulocollic reflex. J Neurol Neurosurg Psychiatry 1994 57 : 190 7.
Colebatch JC, Halmagyi GM. Vestibular evoked potentials in human neck muscle before and after unilateral vestibular deafferentation. Neurology 1992 42 : 1635 6.
Rosengren SM, Colebatch JG. Vestibular evoked potentials (VsEPs) in patients with severe to profound bilateral hearing loss. Clin Neurophysiol 2006 117 : 1145 53.
De Waele C, Tran Ba Huy P, Diard JP, Vidal PP. Saccular dysfunction in Meniere's disease. A vestibular-evoked myogenic potential study. Ann NY Acad Sci 1999 871 : 392 7.
Murofushi T, Matsuzaki M, Mizuno M. Vestibular evoked myogenic potentials in patients with acoustic neuromas. Arch Otolaryngol Head Neck Surg 1998 124 : 509 12.
Murofushi T, Halmagyi GM, Yavor RA, Colebatch JG. Absent vestibular evoked myogenic potentials in vestibular neurolabyrinthitis. An indicator of inferior vestibular nerve involvement? Arch Otolaryngol Head Neck Surg 1996b 122 : 845 8.
Sartucci F, Logi F. Vestibular-evoked myogenic potentials: a method to assess vestibolo-spinal conduction in multiple sclerosis patients. Brain Res Bull 2002 59 : 59 63.
Welgampola MS, Colebatch JG. Characteristics and clinical applications of vestibular-evoked myogenic potentials. Neurology 2005 64 : 1682 8.
Liao L-J, Young Y-H. Vestibular evoked myogenic potentials in basilar artery migraine. Laryngoscope 2004 14 : 1305 9.
Ambrosini A, Maertens de Noordhout A, Schoenen J. Neuromuscular transmission in migraine: a single fiber EMG study in clinical subgroups. Neurology 2001 56 : 1038 43.
Headache Classification Subcommittee of the International Headache Society. The International Classification of Headache Disorders, 2nd edition. Cephalalgia 2004 24 (Suppl. 1).
Akin F, Murname OD, Panus PC, Caruthers SK, Wilkinson AE, Proffitt TM. The influence of voluntary tonic EMG level on the vestibular-evoked myogenic potential. J Rehabil Res Dev 2004 41 : 473 80.
Al-Sebeih K, Zeitouni A. Vestibular-evoked myogenic potentials as a test of otolith function. Med Princ Pract 2002 11 : 136 40.
Rothwell JC, Colebatch JG. Motor unit excitability changes mediatimg vestibulocollic reflexes in the sternocleidomastoid muscle. Clin Neurophysiol 2004 115 : 2567 73.
Uchino Y, Sato H, Sasaki M, Levo H, Isotalo E, Kallela M, et al. Sacculocollic reflex arcs in cats. J Neurophysiol 1997 77 : 3003 12.
Uchino Y, Sato H, Suwa H. Excitatory and inhibitory inputs from saccular afferents to single vestibular neurons in the cat. J Neurophysiol 1997 78 : 2186 92.
Wilson WJ, Schor RH. The neural substrate of the vestibulocollic reflex. What needs to be learned. Exp Brain Res 1999 129 : 483 93.
Kushiro K, Zakir M, Ogawa Y, Sato H, Uchino Y. Saccular and utricular inputs to sternocleidomastoid motoneurons of decerebrate cats. Exp Brain Res 1999 126 : 410 6.
Colebatch JG, Rothwell JC. Vestibular-evoked EMG responses in human neck muscles. J Physiol 1993 473 : 18P.
Deriu F, Tolu E, Rothwell JC. A short latency vestibulomasseteric reflex evoked by electrical stimulation over the mastoid in healthy humans. J Physiol 2003 553 : 267 79.
Deriu F, Tolu E, Rothwell JC. A sound-evoked vestibulomasseteric reflex in healthy humans. J Neurophysiol 2005 93 : 2739 51.
Di Lazzaro V, Quartarone A, Higuchi K, Rothwell JC. Short-latency trigemino-cervical reflexes in man. Exp Brain Res 1995 102 : 471 82.
Milanov I, Bogdanova D. Trigemino-cervical reflex in patients with headache. Cephalalgia 2003 23 : 2335 8.
Di Clemente L, Coppola G, Magis D, Fumal A, De Pasqua V, Di Piero V, Schoenen J. Interictal habituation deficit of the nociceptive blink reflex: an endophenotypic marker for presymptomatic migraine? Brain 2007 130 : 765 70.
Ambrosini A, D'Onofrio M, Grieco GS, Di Mambro A, Montagna G, Fortini D et al. Familial basilar migraine associated with a new mutation in the ATP1A2 gene. Neurology 2005 65 : 1826 8.
Wilson VJ, Zarzecki P, Schor H, Isu N, Rose PK, Sato H, et al. Cortical influences on the vestibular nuclei on the cat. Exp Brain Res 1999 125 : 1 13.
Schoenen J. Deficient habituation of evoked cortical potentials in migraine: a link between brain biology, behavior and trigeminovascular activation? Biomed Pharmacother 1996 50 : 71 8.
Evers S, Quibeldey F, Grotemeyer KH, Suhr B, Husstedt IW. Dynamic changes of cognitive habituation and serotonin metabolism during the migraine interval. Cephalalgia 1999 19 : 485 91.
Schuerger RJ, Balaban CD. Organization of the coeruleo-vestibular pathway in rats, rabbits and monkeys. Brain Res 1999 30 : 189 217.
Buisseret-Delmas C, Compoint C, Delfini C, Buisseret P. Organisation of reciprocal connections between trigeminal and vestibular nuclei in the rat. J Comp Neurol 1999 409 : 153 68.
Áfra J, Proietti Cecchini A, Sándor PS, Schoenen J. Comparison of visual and auditory evoked cortical potentials in migraine patients between attacks. Clin Neurophysiol 2000 111 : 1124 9.
Koo JW, Balaban C. Serotonin-induced plasma extravasation in the murine inner ear: possible mechanism of migraine-associated inner ear dysfunction. Cephalalgia 2006 26 : 1310 9.