Reference : Interictal abnormalities of gamma band activity in visual evoked responses in migrain...
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Neurology
Interictal abnormalities of gamma band activity in visual evoked responses in migraine: an indication of thalamocortical dysrhythmia?
Coppola, G. [> > > >]
Ambrosini, Anna [IRCCS INM Neuromed (Pozzilli, Italy) > Headache Clinic >]
Di Clemente, L. [> > > >]
Magis, Delphine mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie Sart Tilman >]
Fumal, Arnaud mailto [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie CHR >]
Gerard, Pascale [Centre Hospitalier Universitaire de Liège - CHU > > Neurologie CHR >]
Pierelli, F. [> > > >]
Schoenen, Jean mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Neuro-anatomie]
Cephalalgia : An International Journal of Headache
Blackwell Science
Yes (verified by ORBi)
[en] gamma band ; habituation ; migraine ; thalamocortical dysrhythmia ; visual evoked potentials
[en] Between attacks, migraineurs lack habituation in standard visual evoked potentials (VEPs). Visual stimuli also evoke high-frequency oscillations in the gamma band range (GBOs, 20-35 Hz) assumed to be generated both at subcortical (early GBOs) and cortical levels (late GBOs). The consecutive peaks of GBOs were analysed regarding amplitude and habituation in six successive blocks of 100 averaged pattern reversal (PR)-VEPs in healthy volunteers and interictally in migraine with (MA) or without aura patients. Amplitude of the two early GBO components in the first PR-VEP block was significantly increased in MA patients. There was a significant habituation deficit of the late GBO peaks in migraineurs. The increased amplitude of early GBOs could be related to the increased interictal visual discomfort reported by patients. We hypothesize that the hypofunctioning serotonergic pathways may cause, in line with the thalamocortical dysrhythmia theory, a functional disconnection of the thalamus leading to decreased intracortical lateral inhibition, which can induce dishabituation.

File(s) associated to this reference

Fulltext file(s):

Restricted access
VEP gamma band.pdfNo commentaryPublisher postprint179.48 kBRequest copy

Bookmark and Share SFX Query

All documents in ORBi are protected by a user license.