Reference : p63 is a prostate basal cell marker and is required for prostate development.
Scientific journals : Article
Human health sciences : Urology & nephrology
Life sciences : Anatomy (cytology, histology, embryology...) & physiology
p63 is a prostate basal cell marker and is required for prostate development.
Signoretti, Sabina [> > > >]
Waltregny, David mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Labo de recherche sur les métastases - Département des sciences biomédicales et précliniques >]
Dilks, James [> > > >]
Isaac, Beth [> > > >]
Lin, Douglas [> > > >]
Garraway, Levi [> > > >]
Yang, Annie [> > > >]
Montironi, Rondolfo [> > > >]
McKeon, Frank [> > > >]
Loda, Massimo [> > > >]
American Journal of Pathology
American Society for Investigative Pathology
Yes (verified by ORBi)
[en] Adenocarcinoma/metabolism/pathology ; Animals ; Biological Markers ; Cell Nucleus/metabolism ; Cells, Cultured ; DNA-Binding Proteins ; Epithelial Cells/metabolism ; Genes, Tumor Suppressor ; Humans ; Male ; Membrane Proteins ; Mice ; Mice, Inbred Strains ; Neoplasm Invasiveness ; Phosphoproteins/metabolism/physiology ; Prostate/cytology/growth & development/metabolism ; Prostatic Intraepithelial Neoplasia/metabolism/pathology ; Prostatic Neoplasms/metabolism/pathology ; Protein Isoforms/metabolism ; Reference Values ; Trans-Activators ; Tumor Suppressor Proteins
[en] The p53 homologue p63 encodes for different isotypes able to either transactivate p53 reporter genes (TAp63) or act as p53-dominant-negatives (DeltaNp63). p63 is expressed in the basal cells of many epithelial organs and its germline inactivation in the mouse results in agenesis of organs such as skin appendages and the breast. Here, we show that prostate basal cells, but not secretory or neuroendocrine cells, express p63. In addition, prostate basal cells in culture predominantly express the DeltaNp63alpha isotype. In contrast, p63 protein is not detected in human prostate adenocarcinomas. Finally, and most importantly, p63(-/-) mice do not develop the prostate. These results indicate that p63 is required for prostate development and support the hypothesis that basal cells represent and/or include prostate stem cells. Furthermore, our results show that p63 immunohistochemistry may be a valuable tool in the differential diagnosis of benign versus malignant prostatic lesions.

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