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Chloride Permeability of Rat Brain Membrane Vesicles Correlates with Thiamine Triphosphate Content
Bettendorff, Lucien; Hennuy, Benoît; De Clerck, Anne et al.
1994In Brain Research, 652 (1), p. 157-160
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Abstract :
[en] Incubation of rat brain homogenates with thiamine or thiamine diphosphate (TDP) leads to a synthesis of thiamine triphosphate (TTP). In membrane vesicles subsequently prepared from the homogenates, increased TTP content correlates with increased 36Cl- uptake. A hyperbolic relationship was obtained with a K0.5 of 0.27 nmol TTP/mg protein. In crude mitochondrial fractions from the brains of animals previously treated with thiamine or sulbutiamine, a positive correlation between 36Cl- uptake and TTP content was found. These results, together with other results previously obtained with the patch-clamp technique, suggest that TTP is an activator of chloride channels having a large unit conductance.
Disciplines :
Biochemistry, biophysics & molecular biology
Author, co-author :
Bettendorff, Lucien  ;  Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique
Hennuy, Benoît ;  Université de Liège - ULiège > GIGA-Management : Plate-forme transcriptomique
De Clerck, Anne
Wins, Pierre
Language :
English
Title :
Chloride Permeability of Rat Brain Membrane Vesicles Correlates with Thiamine Triphosphate Content
Publication date :
1994
Journal title :
Brain Research
ISSN :
0006-8993
eISSN :
1872-6240
Publisher :
Elsevier, Netherlands
Volume :
652
Issue :
1
Pages :
157-160
Peer reviewed :
Peer Reviewed verified by ORBi
Available on ORBi :
since 23 January 2009

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