Reference : Chloride Permeability of Rat Brain Membrane Vesicles Correlates with Thiamine Triphos...
Scientific journals : Article
Life sciences : Biochemistry, biophysics & molecular biology
Chloride Permeability of Rat Brain Membrane Vesicles Correlates with Thiamine Triphosphate Content
Bettendorff, Lucien mailto [Université de Liège - ULiège > Département des sciences biomédicales et précliniques > Biochimie et physiologie humaine et pathologique >]
Hennuy, Benoît mailto [Université de Liège - ULiège > > GIGA-Management : Plate-forme transcriptomique >]
De Clerck, Anne [> > > >]
Wins, Pierre [> > > >]
Brain Research
Yes (verified by ORBi)
[en] Incubation of rat brain homogenates with thiamine or thiamine diphosphate (TDP) leads to a synthesis of thiamine triphosphate (TTP). In membrane vesicles subsequently prepared from the homogenates, increased TTP content correlates with increased 36Cl- uptake. A hyperbolic relationship was obtained with a K0.5 of 0.27 nmol TTP/mg protein. In crude mitochondrial fractions from the brains of animals previously treated with thiamine or sulbutiamine, a positive correlation between 36Cl- uptake and TTP content was found. These results, together with other results previously obtained with the patch-clamp technique, suggest that TTP is an activator of chloride channels having a large unit conductance.

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