Comparison of deposition images obtained by use of an ultrafine 99m-technetium-labeled carbon dry aerosol with ventilation images obtained by use of 81m-krypton gas for evaluation of pulmonary dysfunction in calves.
Votion, Dominique; Coghe, J. D.; Lekeux, Pierre
2001 • In American Journal of Veterinary Research, 62 (12), p. 1881-6
[en] OBJECTIVE: To characterize the accuracy of an ultrafine 99m-technetium-labeled carbon dry aerosol for use in assessment of regional ventilation in calves with pulmonary dysfunction. ANIMALS: 7 Belgian White and Blue calves. PROCEDURE: The ultrafine aerosol was assessed by comparing deposition (D) images with ventilation (V) images obtained by use of 81 m-krypton (81mKr) gas via D-to-V ratio (D:V) image analysis in calves during spontaneous breathing (SB) and during experimentally induced pulmonary dysfunction (ePD). RESULTS: Mismatching index (LrTot) calculated on the D:V images revealed a good match (LrTot, 0.96 +/- 0.01) between D and V distribution patterns in calves during SB. Calculation of the ultrafine aerosol penetration index relative to 81mKr (PIRel) revealed preferential distribution of the ultrafine aerosol in lung parenchyma (PIRel, 1.13 +/- 0.11). In ePD, heterogeneity in the D:V distribution was observed (LrTot, 0.78 +/- 0.10) as a result of ultrafine aerosol particles impaction in airways as indicated by PIRel (0.66 +/- 0.16) and a proportion of pixels more radioactive in D images, compared with V images, that was located in the central part of the lung (475 +/- 77% in ePD vs 32.8 +/- 5.7% in SB). However, this central deposition did not prevent visual examination of the entire ventilated lung. CONCLUSIONS AND CLINICAL RELEVANCE: The ultrafine aerosol appears suitable for use in examination of ventilated parts of lungs of cattle, even those with impaired pulmonary function. However, airway impaction of ultrafine aerosol particles impedes the quantification of regional ventilation in cattle with abnormal lung function.
Disciplines :
Veterinary medicine & animal health
Author, co-author :
Votion, Dominique ; Université de Liège - ULiège > Département clinique des animaux de compagnie et des équidés > Anesthésiologie gén. et pathologie chirurg. des grds animaux
Coghe, J. D.
Lekeux, Pierre ; Université de Liège - ULiège > Département de sciences fonctionnelles > Physiologie - Doyen de la Faculté de Médecine vétérinaire
Language :
English
Title :
Comparison of deposition images obtained by use of an ultrafine 99m-technetium-labeled carbon dry aerosol with ventilation images obtained by use of 81m-krypton gas for evaluation of pulmonary dysfunction in calves.
Publication date :
2001
Journal title :
American Journal of Veterinary Research
ISSN :
0002-9645
eISSN :
1943-5681
Publisher :
American Veterinary Medical Association, Schaumburg, United States - Illinois
Burch W.M., Tetley I.J., Gras J.L. (1984) 99Tcm-"pseudogas". An ultrafine monodisperse aerosol for diagnostic studies in the lung. Australas Phys Eng Sci Med 7:146-149.
Sullivan P.J., Burke W.M., Burch W.M. (1988) A clinical comparison of Technegas and xenon-133 in 50 patients with suspected pulmonary embolus. Chest 94:300-304.
Zhang X., Hirano H., Yamamoto K. (1996) Technegas ventilation SPECT for evaluating silicosis in comparison with computed tomography. Ann Nucl Med 10:165-170.
Basoglu T., Canbaz F., Bernay I. (1998) Bilateral pulmonary artery aneurysms in a patient with Behcet syndrome: Evaluation with radionuclide angiography and V/Q lung scanning. Clin Nucl Med 23:735-738.
Sasaki Y., Imai T., Shinkai T. (1998) Estimation of regional lung function in interstitial pulmonary disease using 99mTc-technegas and 99mTc-macroaggregated albumin single-photon emission tomography. Eur J Nucl Med 25:1623-1629.
Howarth D.M., Lan L., Thomas P.A. (1999) 99mTc technegas ventilation and perfusion lung scintigraphy for the diagnosis of pulmonary embolus. J Nucl Med 40:579-584.
Bomanji J., Alawadhi H., Beale A. (1992) Clinical outcomes of patients with suspected pulmonary embolism using 99Tcm-Technegas as a ventilatory agent for lung scanning. Nucl Med Commun 13:467-477.
Kropp J., Overbeck B., Klumpp J. (1993) Inhalation scintigraphy with an ultrafine aerosol in infants with functional bronchial stenoses. Clin Nucl Med 18:223-226.
DeGeeter F., Bossuyt A., Jonckheer M. (1989) Comparison of Technegas to 81mKr as ventilation agent. Eur J Nucl Med 5:442.
Peltier P., De Faucal P., Chetanneau A. (1990) Comparison of technetium-99m aerosol and krypton-81m in ventilation studies for the diagnosis of pulmonary embolism. Nucl Med Commun 11:631-638.
Rimkus D.S., Ashburn W.L. (1990) Lung ventilation scanning with a new carbon particle radioaerosol (Technegas): Preliminary patient studies. Clin Nucl Med 15:222-226.
Satoh K., Takahashi K., Sasaki M. (1997) Comparison of 99mTc-Technegas SPECT with 133Xe dynamic SPECT in pulmonary emphysema. Ann Nucl Med 11:201-206.
Jensen R., Pierson R.E., Braddy P.M. (1976) Diseases of yearling feedlot cattle in Colorado. J Am Vet Med Assoc 169:497-499.
Muggli-Cockett N.E., Cundiff L.V., Gregory K.E. (1992) Genetic analysis of bovine respiratory disease in beef calves during the first year of life. J Anim Sci 70:2013-2019.
Coghe J., Votion D., Lekeux P. (2000) Comparison between radioactive aerosol, Technegas and Krypton for ventilation imaging in healthy calves. Vet J 160:25-32.
Andrew G.A., Kennedy G.A. (1997) Respiratory diagnostic pathology. Vet Clin North Am Food Anim Pract 13:515-547.
Goldberg I.S., Lourenco R.V. (1973) Deposition of aerosols in pulmonary disease. Arch Intern Med 131:88-91.
Lippmann M., Yeates D.B., Albert R.E. (1980) Deposition, retention, and clearance of inhaled particles. Br J Ind Med 37:337-362.
Desmecht D.J., Linden A.S., Rollin F.A. (1992) Effect of intravenous and aerosol administration of 5-hydroxytryptamine on pulmonary function values in healthy calves Am. J Vet Res 53:315-320.
Hastings D.L., Jeans S.P., Wall W.H. (1995) The effect on diagnostic quality of using dual isotope imaging for 81Krm ventilation and 99Tcm-MAA perfusion lung scanning. Nucl Med Commun 16:281-289.
Greening A.P., Miniati M., Fazio F. (1980) Regional deposition of aerosols in health and in airways obstruction: A comparison with krypton-81m ventilation scanning. Bull Eur Physiopathol Respir 16:287-298.
Emmett P.C., Love R.G., Hannan W.J. (1984) The relationship between the pulmonary distribution of inhaled fine aerosols and tests of small airway function. Bull Eur Physiopathol Respir 20:325-332.
Van den Brom W.E., Clercx C., Van Toor A.J. (1989) Quantitative analysis of radioaerosol inhalation and perfusion scintigraphy in dogs. Lung 167:201-212.
Votion D., Vandenput S., Duvivier D.H. (1997) Analysis of equine scintigraphical lung images. Vet J 153:49-61.
Lekeux P. (1991) Particularités physiologiques et physiopathologiques de la fonction pulmonaire des bovins. Point Vét 23:793-799.
Lloyd J.J., James J.M., Shields R.A. (1994) The influence of inhalation technique on Technegas particle deposition and image appearance in normal volunteers. Eur J Nucl Med 21:394-398.
Line B.R. (1992) Go with the flow-but how far?. J Nucl Med 33:1939-1942.
Strong J.C., Agnew J.E. (1989) The particle size distribution of Technegas and its influence on regional lung deposition. Nucl Med Commun 10:425-430.
Lloyd J.J., Shields R.A., Taylor C.J. (1995) Technegas and Pertechnegas particle size distribution. Eur J Nucl Med 22:473-476.
Isawa T., Lee B.-T., Hiraga K. (1996) High-resolution electron microscopy of technegas and pertechnegas. Nucl Med Commun 17:147-152.
Senden T.J., Moock K.H., Gerald J.F. (1997) The physical and chemical nature of technegas. J Nucl Med 38:1327-1333.
Lopez-Vidriero M.T. (1984) Lung secretions. Aerosols and the lung: Clinical and Experimental Aspects. , Clarke SW, Pavia D, eds. London: Butterworth & Co; 19-48.
Lippmann M., Yeates D.B., Albert R.E. (1980) Deposition, retention and clearance of inhaled particles. Br J Ind Med 37:337-362.
Amis T.C., Jones T. (1980) Krypton-81m as a flow tracer in the lung: Theory and quantitation. Bull Eur Physiopathol Respir 16:245-259.
Votion D.M., Ghafir Y., Vandenput S. (1999) Analysis of scintigraphical lung images before and after treatment of horses suffering from chronic pulmonary disease Vet. Rec 144:232-236.
Davis S.S., Hardy J.G., Newman S.P. (1992) Gamma scintigraphy in the evaluation of pharmaceutical dosage forms. Eur J Nucl Med 19:971-986.
Newman S.P. (1993) Scintigraphic assessment of therapeutic aerosols. Crit Rev Ther Drug Carrier Syst 10:65-109.
Verbanck S., Koneru S., Cohen M. (1993) Controlled delivery of Krypton-81m boli in normal subjects: Results and implications. J Nucl Med 34:1859-1865.
Klumper A., Zwijnenburg A. (1986) Dual isotope (81Krm and 99Tcm) SPECT in lung function diagnosis. Phys Med Biol 31:751-761.
Tominaga S., Fukuchi Y., Mori Y. (1998) Evaluation by ventilation and perfusion scintigraphy in patients who developed postural hypoxemia in the supine position. Ann Nucl Med 12:249-254.
West J.B. (1977) Ventilation-perfusion relationships. Am Rev Respir Dis 116:919-943.