Reference : Is ethanol a pro-drug? The role of acetaldehyde in the central effects of ethanol
Scientific journals : Article
Social & behavioral sciences, psychology : Neurosciences & behavior
Human health sciences : Psychiatry
Human health sciences : Pharmacy, pharmacology & toxicology
http://hdl.handle.net/2268/4410
Is ethanol a pro-drug? The role of acetaldehyde in the central effects of ethanol
English
Quertemont, Etienne mailto [Université de Liège - ULiège > Département des sciences cognitives > Psychologie quantitative >]
Tambour, Sophie [Université de Liège - ULiège > Département des sciences cognitives > Neuroscience comportementale et psychopharmacologie expér. >]
2004
Trends in Pharmacological Sciences
Elsevier Science London
25
3
130-134
Yes (verified by ORBi)
International
0165-6147
1873-3735
London
[en] Ethanol ; Acetaldehyde ; Alcoholism ; Metabolism ; Catalase
[en] Acetaldehyde, the first product of ethanol metabolism, has been speculated to be involved in many behavioral effects of ethanol. However, its precise role remains a matter of debate, with some researchers suggesting that acetaldehyde has no role in the effects of ethanol and others contending that ethanol is a pro-drug whose pharmacological action is mediated by acetaldehyde. Recent studies support a role for acetaldehyde in the stimulant, reinforcing, hypnotic and amnesic effects of ethanol, and, in particular, alcohol abuse and alcoholism. However, current evidence indicates that acetaldehyde is not involved in some of the major neurochemical effects of ethanol. It is therefore likely that ethanol and acetaldehyde molecules act synergistically to determine the multiple neurochemical and behavioral effects of alcohol consumption.
Centre de Neurosciences Cognitives et Comportementales
Fonds de la Recherche Scientifique (Communauté française de Belgique) - F.R.S.-FNRS
Researchers ; Professionals
http://hdl.handle.net/2268/4410
10.1016/j.tips.2004.01.001

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