Article (Scientific journals)
Acute experimental glomerulonephritis induced by the glomerular deposition of circulating polymerid IgA-Concanavalin A complexes
Davin, Jean-Claude; Dechenne, Charles; Lombet, Jacques et al.
1989In Virchows Archiv. A: Pathological Anatomy and Histopathology, 415 (1), p. 7-20
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Abstract :
[en] The perfusion of polymeric or secretory IgA-Concanavalin A complexes into the aorta of rats led to a mannose-dependent binding of both IgA and lectin to the glomerular capillary wall, as shown by double immunolocalization experiments, by quantitative analysis of the amount of radiolabeled complexes bound per g of kidney, and by blocking experiments with the corresponding carbohydrate. Rats injected with amounts of those complexes as low as 500 ?g developed, one hour later, a focal and segmental proliferative glomerulonephritis characterized by the deposition of injected complexes and of rat C3 and rat fibrin/ fibrinogen in most glomeruli ; focal thrombosis and small areas of necrosis in 10 to 15% of glomeruli, confined to the periphery of a single lobule of the tuft and segmental infiltration of these glomeruli by polymorphonuclear leucocytes and platelets. At the same time, many mesangial cells exhibited a hyperactive appearance, and red blood cells were noted in tubular lumens. In contrast, rats similarly injected with either monomeric IgA-ConA complexes, multimeric or secretory IgA-peanut agglutinin complexes or polymeric or monomeric IgA aggregates of comparable apparent molecular weight did not develop obvious glomerular lesions within one hour. The data indicate that preformed polymeric IgA-ConA complexes can specifically bind to glomerular structures in vivo and trigger acute glomerular lesions locally, analogous to those observed in some glomerular diseases associated with a cryoglobulinemia.
Disciplines :
Anatomy (cytology, histology, embryology...) & physiology
Author, co-author :
Davin, Jean-Claude ;  Université de Liège - ULiège
Dechenne, Charles ;  Centre Hospitalier Universitaire de Liège - CHU > Néphrologie
Lombet, Jacques ;  Université de Liège - ULiège > Département des sciences cliniques > Pédiatrie
Rentier, Bernard  ;  Université de Liège - ULiège > Laboratoire de Microbiologie générale et médicale
Foidart, J. B.;  Université de Liège - ULiège
Mahieu, P. R.;  Université de Liège - ULiège
Language :
English
Title :
Acute experimental glomerulonephritis induced by the glomerular deposition of circulating polymerid IgA-Concanavalin A complexes
Publication date :
1989
Journal title :
Virchows Archiv. A: Pathological Anatomy and Histopathology
ISSN :
0174-7398
Publisher :
Springer verlag
Volume :
415
Issue :
1
Pages :
7-20
Peer reviewed :
Peer Reviewed verified by ORBi
Commentary :
The original publication is available at http://www.springerlink.com/content/k566623xp2042622/fulltext.pdf
Available on ORBi :
since 13 January 2009

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